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Several cases of colorectal, gastric, pancreatic, ovarian and cervical cancers showed moderate to strong immunoreactivity. Remaining tumour tissues were weakly stained or weakly stained.
Tumour tissues generally exhibited moderate cytoplasmic immunoreactivity often combined with nuclear staining. Renal cancers were mainly negative.
GENE INFORMATION
Gene name
AOAH
Synonyms
Description
Acyloxyacyl hydrolase (neutrophil) (HGNC Symbol)
Entrez gene summary
This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides, effectively detoxifying these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative bacteria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Apr 2010]
