Tissue expression of AOAH - Summary - The Human Protein Atlas

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AOAH

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	AOAH
Gene description	Acyloxyacyl hydrolase (neutrophil)
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (spleen)
GTEx:	Tissue enriched (spleen)
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several different tissue types.

DATA RELIABILITY
Data reliability description	Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 2 antibodies. HPA021666 , HPA026716
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

N/A

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	AOAH
Synonyms
Description	Acyloxyacyl hydrolase (neutrophil) (HGNC Symbol)
Entrez gene summary	This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides, effectively detoxifying these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative bacteria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Apr 2010]
Chromosome	7
Cytoband	p14.2
Chromosome location (bp)	36512949 - 36724549
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136250 (version 83.38)
Entrez gene	313
UniProt	P28039 (UniProt - Evidence at protein level)
neXtProt	NX_P28039
Antibodypedia	AOAH antibodies

PROTEIN BROWSER

AOAH-001	AOAH-002	AOAH-004	AOAH-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AOAH-001 ENSP00000483783 ENST00000617537	P28039 [Direct mapping] Acyloxyacyl hydrolase Acyloxyacyl hydrolase small subunit Acyloxyacyl hydrolase large subunit Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004465 [lipoprotein lipase activity] GO:0005576 [extracellular region] GO:0006629 [lipid metabolic process] GO:0006954 [inflammatory response] GO:0016788 [hydrolase activity, acting on ester bonds] GO:0050528 [acyloxyacyl hydrolase activity] Show all	575 aa 65.1 kDa	Yes	0
AOAH-002 ENSP00000479664 ENST00000617267	A0A087WVT3 [Direct mapping] Acyloxyacyl hydrolase Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0008653 [lipopolysaccharide metabolic process] GO:0016788 [hydrolase activity, acting on ester bonds] GO:0050528 [acyloxyacyl hydrolase activity] GO:0050728 [negative regulation of inflammatory response] Show all	688 aa 77.9 kDa	Yes	0
AOAH-004 ENSP00000416051 ENST00000435386	C9JJA7 [Direct mapping] Acyloxyacyl hydrolase Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		108 aa 12.1 kDa	Yes	0
AOAH-201 ENSP00000484305 ENST00000612871	P28039 [Direct mapping] Acyloxyacyl hydrolase Acyloxyacyl hydrolase small subunit Acyloxyacyl hydrolase large subunit Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004465 [lipoprotein lipase activity] GO:0005576 [extracellular region] GO:0006629 [lipid metabolic process] GO:0006954 [inflammatory response] GO:0016788 [hydrolase activity, acting on ester bonds] GO:0050528 [acyloxyacyl hydrolase activity] Show all	543 aa 61.6 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.