Cell atlas - ZFHX2 - The Human Protein Atlas

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ZFHX2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli fibrillar center
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ZFHX2
Gene description	Zinc finger homeobox 2
Protein class	Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli (fibrillar center). In addition localized to the nucleus.
RNA cell category	Cell line enhanced (AN3-CA)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli fibrillar center (approved)
Additional location	In addition localized to the Nucleus (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA000720
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AN3-CA) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli (fibrillar center). In addition localized to the nucleus.

Main location

Nucleoli fibrillar center (approved)

Additional location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA000720	A549	Nucleus
	HPA000720	A549	Nucleoli fibrillar center
	HPA000720	SH-SY5Y	Nucleus
			Nucleoli fibrillar center
			Cytosol
	HPA000720	U-2 OS	Nucleus	Intensity
			Nucleoli fibrillar center	Intensity
			Cytosol	Intensity

GENE INFORMATION
Gene name	ZFHX2 (HGNC Symbol)
Synonyms	KIAA1056, KIAA1762, ZFH-5, ZNF409
Description	Zinc finger homeobox 2 (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	23520855 - 23556192
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136367 (version 83.38)
Entrez gene	85446
UniProt	Q9C0A1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9C0A1
Antibodypedia	ZFHX2 antibodies

PROTEIN BROWSER

ZFHX2-001	ZFHX2-004	ZFHX2-005	ZFHX2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZFHX2-001 ENSP00000413418 ENST00000419474	Q9C0A1 [Direct mapping] Zinc finger homeobox protein 2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0030534 [adult behavior] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	2572 aa 274.2 kDa	No	0
ZFHX2-004 ENSP00000409464 ENST00000412565	C9JSX6 [Direct mapping] Zinc finger homeobox protein 2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046872 [metal ion binding] Show all	361 aa 37.9 kDa	No	0
ZFHX2-005 ENSP00000451342 ENST00000555334	G3V3N5 [Direct mapping] Zinc finger homeobox protein 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		246 aa 25.8 kDa	No	0
ZFHX2-201 ENSP00000478696 ENST00000615307	A2RRC6 [Direct mapping] ZFHX2 protein; Zinc finger homeobox protein 2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046872 [metal ion binding] Show all	408 aa 43.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.