Cell atlas - VEZF1 - The Human Protein Atlas

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VEZF1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS siRNA

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	VEZF1
Gene description	Vascular endothelial zinc finger 1
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
siRNA	The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA027520
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ASSAYS

RNA expression

Human cells

siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA027520	A-431	Nucleoplasm
HPA027520	U-2 OS	Nucleoplasm
HPA027520	U-251 MG	Nucleoplasm

siRNA VALIDATION

Relative fluorescence intensity (RFI)

Antibody

HPA027520

siRNA validation

Validated: Significant downregulation > 25% by both siRNA:s.

Analysis performed in

Nuclear region of segmented cells in 10x-images

siRNA 1

siRNA 2

RFI

31%

37%

p-value

< 0.01


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Sample	Cell line
HPA027520	siRNA 1	U-2 OS
HPA027520	siRNA 2	U-2 OS
HPA027520	scrambled	U-2 OS

GENE INFORMATION
Gene name	VEZF1 (HGNC Symbol)
Synonyms	DB1, ZNF161
Description	Vascular endothelial zinc finger 1 (HGNC Symbol)
Entrez gene summary	Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. ZNF161 is a C2H2-type zinc finger protein (Koyano-Nakagawa et al., 1994 [PubMed 8035792]). See MIM 603971 for general information on zinc finger proteins.[supplied by OMIM, Sep 2008]
Chromosome	17
Cytoband	q22
Chromosome location (bp)	57971547 - 57988259
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136451 (version 83.38)
Entrez gene	7716
UniProt	Q14119 (UniProt - Evidence at protein level)
neXtProt	NX_Q14119
Antibodypedia	VEZF1 antibodies

PROTEIN BROWSER

VEZF1-001	VEZF1-002	VEZF1-004	VEZF1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VEZF1-001 ENSP00000462337 ENST00000581208	Q14119 [Direct mapping] Vascular endothelial zinc finger 1 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001885 [endothelial cell development] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006968 [cellular defense response] GO:0046872 [metal ion binding] Show all	521 aa 56.9 kDa	No	0
VEZF1-002 ENSP00000464687 ENST00000584396	J3QSH4 [Direct mapping] Vascular endothelial zinc finger 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0046872 [metal ion binding] Show all	512 aa 55.8 kDa	No	0
VEZF1-004 ENSP00000463631 ENST00000583932	J3QLN5 [Direct mapping] Vascular endothelial zinc finger 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		16 aa 1.8 kDa	No	0
VEZF1-005 ENSP00000258963 ENST00000258963	J9JIC7 [Direct mapping] Vascular endothelial zinc finger 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	340 aa 37.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.