Expression of BRIP1 in cancer - Summary

CANCER ATLAS

Gene description

BRCA1 interacting protein C-terminal helicase 1

Protein class

Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA005474

GENE INFORMATION
Gene name	BRIP1 (HGNC Symbol)
Synonyms	BACH1, FANCJ, OF
Description	BRCA1 interacting protein C-terminal helicase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q23.2
Chromosome location (bp)	61681266 - 61863521
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136492 (version 83.38)
Entrez gene	83990
UniProt	Q9BX63 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BX63
Antibodypedia	BRIP1 antibodies

PROTEIN BROWSER

BRIP1-001	BRIP1-002	BRIP1-003	BRIP1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BRIP1-001 ENSP00000259008 ENST00000259008	Q9BX63 [Direct mapping] Fanconi anemia group J protein A0A024QZ45 [Target identity:100%; Query identity:100%] BRCA1 interacting protein C-terminal helicase 1, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000077 [DNA damage checkpoint] GO:0000724 [double-strand break repair via homologous recombination] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0004003 [ATP-dependent DNA helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008026 [ATP-dependent helicase activity] GO:0008285 [negative regulation of cell proliferation] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides] GO:0031965 [nuclear membrane] GO:0032508 [DNA duplex unwinding] GO:0044281 [small molecule metabolic process] GO:0045003 [double-strand break repair via synthesis-dependent strand annealing] GO:0046872 [metal ion binding] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0071295 [cellular response to vitamin] Show all	1249 aa 140.9 kDa	No	0
BRIP1-002 ENSP00000464654 ENST00000577598	J3QSE8 [Direct mapping] Fanconi anemia group J protein Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0004003 [ATP-dependent DNA helicase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006139 [nucleobase-containing compound metabolic process] GO:0008026 [ATP-dependent helicase activity] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides] GO:0032508 [DNA duplex unwinding] Show all	994 aa 112.5 kDa	No	0
BRIP1-003 ENSP00000462274 ENST00000577913	J3KS24 [Direct mapping] Fanconi anemia group J protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] Show all	69 aa 7.5 kDa	No	0
BRIP1-006 ENSP00000463272 ENST00000584322	J3QKX0 [Direct mapping] Fanconi anemia group J protein Show all	Phobius predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005524 [ATP binding] GO:0006139 [nucleobase-containing compound metabolic process] GO:0008026 [ATP-dependent helicase activity] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides] Show all	180 aa 19.6 kDa	No	0