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TANK

CANCER ATLAS

Gene description

 TRAF family member-associated NFKB activator

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037675
HPA037676
CAB010345

GENE INFORMATION

Gene name

 TANK (HGNC Symbol)

Synonyms

 I-TRAF, TRAF2

Description

 TRAF family member-associated NFKB activator (HGNC Symbol)

Entrez gene summary

 The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Chromosome

 2

Cytoband

 q24.2

Chromosome location (bp)

 161136908 - 161236221

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136560 (version 83.38)

Entrez gene

 10010

UniProt

 Q92844 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92844

Antibodypedia

 TANK antibodies

PROTEIN BROWSER
«
TANK-001
TANK-002
TANK-003
TANK-004
TANK-006
TANK-008
TANK-012
TANK-014
TANK-015
TANK-016
TANK-020
TANK-023
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TANK-001
ENSP00000259075
ENST00000259075
Q92844 [Direct mapping]
TRAF family member-associated NF-kappa-B activator
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
Show all
 425 aa
47.8 kDa 		No 0
TANK-002
ENSP00000376505
ENST00000392749
Q92844 [Direct mapping]
TRAF family member-associated NF-kappa-B activator
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
Show all
 425 aa
47.8 kDa 		No 0
TANK-003
ENSP00000385983
ENST00000403609
Q92844 [Direct mapping]
TRAF family member-associated NF-kappa-B activator
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
Show all
 119 aa
13.6 kDa 		No 0
TANK-004
ENSP00000385487
ENST00000405852
E7EQA9 [Direct mapping]
TRAF family member-associated NF-kappa-B activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
 408 aa
46.2 kDa 		No 0
TANK-006
ENSP00000399934
ENST00000440506
E7EWR8 [Direct mapping]
TRAF family member-associated NF-kappa-B activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
 105 aa
12.2 kDa 		No 0
TANK-008
ENSP00000384492
ENST00000406287
E7EVA2 [Direct mapping]
TRAF family member-associated NF-kappa-B activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
 238 aa
27.5 kDa 		No 0
TANK-012
ENSP00000392776
ENST00000456358
E7EMT6 [Direct mapping]
TRAF family member-associated NF-kappa-B activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
 165 aa
18.8 kDa 		No 0
TANK-014
ENSP00000384235
ENST00000402568
E7EW82 [Direct mapping]
TRAF family member-associated NF-kappa-B activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
 239 aa
27.6 kDa 		No 0
TANK-015
ENSP00000398157
ENST00000432002
E7EV32 [Direct mapping]
TRAF family member-associated NF-kappa-B activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
 138 aa
15.9 kDa 		No 0
TANK-016
ENSP00000411041
ENST00000429217
E7ENY2 [Direct mapping]
TRAF family member-associated NF-kappa-B activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
 190 aa
21.9 kDa 		No 0
TANK-020
ENSP00000387439
ENST00000439442
H7BZ28 [Direct mapping]
TRAF family member-associated NF-kappa-B activator
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 198 aa
21.8 kDa 		No 0
TANK-023
ENSP00000412556
ENST00000437623
H7C3L4 [Direct mapping]
TRAF family member-associated NF-kappa-B activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 275 aa
30.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.