Tissue expression of TANK - Summary - The Human Protein Atlas

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TANK

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TANK
Gene description	TRAF family member-associated NFKB activator
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 3 antibodies. HPA037675 , HPA037676 , CAB010345
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	TANK (HGNC Symbol)
Synonyms	I-TRAF, TRAF2
Description	TRAF family member-associated NFKB activator (HGNC Symbol)
Entrez gene summary	The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Chromosome	2
Cytoband	q24.2
Chromosome location (bp)	161136908 - 161236221
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136560 (version 83.38)
Entrez gene	10010
UniProt	Q92844 (UniProt - Evidence at protein level)
neXtProt	NX_Q92844
Antibodypedia	TANK antibodies

PROTEIN BROWSER

TANK-001	TANK-002	TANK-003	TANK-004	TANK-006	TANK-008	TANK-012	TANK-014	TANK-015	TANK-016	TANK-020	TANK-023

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TANK-001 ENSP00000259075 ENST00000259075	Q92844 [Direct mapping] TRAF family member-associated NF-kappa-B activator Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0031625 [ubiquitin protein ligase binding] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] Show all	425 aa 47.8 kDa	No	0
TANK-002 ENSP00000376505 ENST00000392749	Q92844 [Direct mapping] TRAF family member-associated NF-kappa-B activator Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0031625 [ubiquitin protein ligase binding] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] Show all	425 aa 47.8 kDa	No	0
TANK-003 ENSP00000385983 ENST00000403609	Q92844 [Direct mapping] TRAF family member-associated NF-kappa-B activator Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0031625 [ubiquitin protein ligase binding] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] Show all	119 aa 13.6 kDa	No	0
TANK-004 ENSP00000385487 ENST00000405852	E7EQA9 [Direct mapping] TRAF family member-associated NF-kappa-B activator Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	408 aa 46.2 kDa	No	0
TANK-006 ENSP00000399934 ENST00000440506	E7EWR8 [Direct mapping] TRAF family member-associated NF-kappa-B activator Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	105 aa 12.2 kDa	No	0
TANK-008 ENSP00000384492 ENST00000406287	E7EVA2 [Direct mapping] TRAF family member-associated NF-kappa-B activator Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	238 aa 27.5 kDa	No	0
TANK-012 ENSP00000392776 ENST00000456358	E7EMT6 [Direct mapping] TRAF family member-associated NF-kappa-B activator Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	165 aa 18.8 kDa	No	0
TANK-014 ENSP00000384235 ENST00000402568	E7EW82 [Direct mapping] TRAF family member-associated NF-kappa-B activator Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	239 aa 27.6 kDa	No	0
TANK-015 ENSP00000398157 ENST00000432002	E7EV32 [Direct mapping] TRAF family member-associated NF-kappa-B activator Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	138 aa 15.9 kDa	No	0
TANK-016 ENSP00000411041 ENST00000429217	E7ENY2 [Direct mapping] TRAF family member-associated NF-kappa-B activator Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	190 aa 21.9 kDa	No	0
TANK-020 ENSP00000387439 ENST00000439442	H7BZ28 [Direct mapping] TRAF family member-associated NF-kappa-B activator Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		198 aa 21.8 kDa	No	0
TANK-023 ENSP00000412556 ENST00000437623	H7C3L4 [Direct mapping] TRAF family member-associated NF-kappa-B activator Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		275 aa 30.6 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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