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Tumor tissues displayed cytoplasmic positivity with varying intensities often weak to moderate. Malignant melanomas, testis, colo-rectal and stomach cancers exhibited moderate positivity. Virtually no staining of ovarian, prostate and renal cancers.
Some urothelial cancers showed moderate cytoplasmic and membranous staining. Remaining malignant cells were negative.
GENE INFORMATION
Gene name
GYPC (HGNC Symbol)
Synonyms
CD236, CD236R, Ge, GPC, GYPD
Description
Glycophorin C (Gerbich blood group) (HGNC Symbol)
Entrez gene summary
Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
