Expression of STAM in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA043882	CAB034399

GENE INFORMATION
Gene name	STAM (HGNC Symbol)
Synonyms	STAM1
Description	Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
Chromosome	10
Cytoband	p12.33
Chromosome location (bp)	17644125 - 17715914
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136738 (version 83.38)
Entrez gene	8027
UniProt	Q92783 (UniProt - Evidence at protein level)
neXtProt	NX_Q92783
Antibodypedia	STAM antibodies

PROTEIN BROWSER

STAM-001	STAM-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STAM-001 ENSP00000366746 ENST00000377524	Q92783 [Direct mapping] Signal transducing adapter molecule 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006886 [intracellular protein transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0009967 [positive regulation of signal transduction] GO:0016197 [endosomal transport] GO:0031901 [early endosome membrane] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0061024 [membrane organization] GO:1903543 [positive regulation of exosomal secretion] GO:1903551 [regulation of extracellular exosome assembly] Show all	540 aa 59.2 kDa	No	0
STAM-003 ENSP00000366721 ENST00000377500	A6NMU3 [Direct mapping] Signal transducing adapter molecule 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] Show all	173 aa 19.2 kDa	No	0