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STAM

GENERAL INFORMATION

Gene name

 STAM

Gene description

 Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA043882 , CAB034399
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 STAM (HGNC Symbol)

Synonyms

 STAM1

Description

 Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]

Chromosome

 10

Cytoband

 p12.33

Chromosome location (bp)

 17644125 - 17715914

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136738 (version 83.38)

Entrez gene

 8027

UniProt

 Q92783 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92783

Antibodypedia

 STAM antibodies

PROTEIN BROWSER
STAM-001
STAM-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STAM-001
ENSP00000366746
ENST00000377524
Q92783 [Direct mapping]
Signal transducing adapter molecule 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0016197 [endosomal transport]
GO:0031901 [early endosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0061024 [membrane organization]
GO:1903543 [positive regulation of exosomal secretion]
GO:1903551 [regulation of extracellular exosome assembly]
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 540 aa
59.2 kDa 		No 0
STAM-003
ENSP00000366721
ENST00000377500
A6NMU3 [Direct mapping]
Signal transducing adapter molecule 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
Show all
 173 aa
19.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.