Expression of GAD2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA044637	CAB078177

GENE INFORMATION
Gene name	GAD2 (HGNC Symbol)
Synonyms	GAD65
Description	Glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (HGNC Symbol)
Entrez gene summary	This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]
Chromosome	10
Cytoband	p12.1
Chromosome location (bp)	26216307 - 26304558
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136750 (version 83.38)
Entrez gene	2572
UniProt	Q05329 (UniProt - Evidence at protein level)
neXtProt	NX_Q05329
Antibodypedia	GAD2 antibodies

PROTEIN BROWSER

GAD2-001	GAD2-002	GAD2-003	GAD2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GAD2-001 ENSP00000365437 ENST00000376261	Q05329 [Direct mapping] Glutamate decarboxylase 2 Q5VZ30 [Target identity:100%; Query identity:100%] Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa); Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa), isoform CRA_b Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004351 [glutamate decarboxylase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006540 [glutamate decarboxylation to succinate] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0016595 [glutamate binding] GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0030054 [cell junction] GO:0030170 [pyridoxal phosphate binding] GO:0030424 [axon] GO:0030672 [synaptic vesicle membrane] GO:0031225 [anchored component of membrane] GO:0031410 [cytoplasmic vesicle] GO:0042136 [neurotransmitter biosynthetic process] GO:0042493 [response to drug] GO:0042734 [presynaptic membrane] GO:0045202 [synapse] GO:0046982 [protein heterodimerization activity] GO:0048471 [perinuclear region of cytoplasm] GO:0060077 [inhibitory synapse] GO:0061202 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] Show all	585 aa 65.4 kDa	No	0
GAD2-002 ENSP00000259271 ENST00000259271	Q05329 [Direct mapping] Glutamate decarboxylase 2 Q5VZ30 [Target identity:100%; Query identity:100%] Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa); Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa), isoform CRA_b Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004351 [glutamate decarboxylase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0030054 [cell junction] GO:0030170 [pyridoxal phosphate binding] GO:0042136 [neurotransmitter biosynthetic process] GO:0042734 [presynaptic membrane] GO:0061202 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] Show all	585 aa 65.4 kDa	No	0
GAD2-003 ENSP00000390434 ENST00000428517	Q5VZ31 [Direct mapping] Glutamate decarboxylase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		188 aa 20.6 kDa	No	0
GAD2-004 ENSP00000365424 ENST00000376248	Q5VZ29 [Direct mapping] Glutamate decarboxylase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0030170 [pyridoxal phosphate binding] Show all	129 aa 14.8 kDa	No	0