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GAD2

GENERAL INFORMATION

Gene name

 GAD2

Gene description

 Glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Tissue enhanced (caudate, hypothalamus)
FANTOM5:Tissue enriched (caudate)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct expression in islets of Langerhans and CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA044637 , CAB078177
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (caudate)

GENE INFORMATION

Gene name

 GAD2 (HGNC Symbol)

Synonyms

 GAD65

Description

 Glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (HGNC Symbol)

Entrez gene summary

 This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]

Chromosome

 10

Cytoband

 p12.1

Chromosome location (bp)

 26216307 - 26304558

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136750 (version 83.38)

Entrez gene

 2572

UniProt

 Q05329 (UniProt - Evidence at protein level)

neXtProt

 NX_Q05329

Antibodypedia

 GAD2 antibodies

PROTEIN BROWSER
GAD2-001
GAD2-002
GAD2-003
GAD2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GAD2-001
ENSP00000365437
ENST00000376261
Q05329 [Direct mapping]
Glutamate decarboxylase 2
Q5VZ30 [Target identity:100%; Query identity:100%]
Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa); Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa), isoform CRA_b
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Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0004351 [glutamate decarboxylase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006540 [glutamate decarboxylation to succinate]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0016595 [glutamate binding]
GO:0016831 [carboxy-lyase activity]
GO:0019752 [carboxylic acid metabolic process]
GO:0030054 [cell junction]
GO:0030170 [pyridoxal phosphate binding]
GO:0030424 [axon]
GO:0030672 [synaptic vesicle membrane]
GO:0031225 [anchored component of membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042493 [response to drug]
GO:0042734 [presynaptic membrane]
GO:0045202 [synapse]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0060077 [inhibitory synapse]
GO:0061202 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
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 585 aa
65.4 kDa 		No 0
GAD2-002
ENSP00000259271
ENST00000259271
Q05329 [Direct mapping]
Glutamate decarboxylase 2
Q5VZ30 [Target identity:100%; Query identity:100%]
Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa); Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa), isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0004351 [glutamate decarboxylase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0016831 [carboxy-lyase activity]
GO:0019752 [carboxylic acid metabolic process]
GO:0030054 [cell junction]
GO:0030170 [pyridoxal phosphate binding]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042734 [presynaptic membrane]
GO:0061202 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
Show all
 585 aa
65.4 kDa 		No 0
GAD2-003
ENSP00000390434
ENST00000428517
Q5VZ31 [Direct mapping]
Glutamate decarboxylase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 188 aa
20.6 kDa 		No 0
GAD2-004
ENSP00000365424
ENST00000376248
Q5VZ29 [Direct mapping]
Glutamate decarboxylase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016831 [carboxy-lyase activity]
GO:0019752 [carboxylic acid metabolic process]
GO:0030170 [pyridoxal phosphate binding]
Show all
 129 aa
14.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.