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ABI1

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GENERAL INFORMATION

Gene name

 ABI1

Gene description

 Abl-interactor 1

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 12
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the plasma membrane & cell junctions.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (supported), Cell Junctions (supported)

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA029973 , HPA068407
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the plasma membrane & cell junctions.

Main location

 Plasma membrane (supported), Cell Junctions (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA029973 A-431 No staining    
HPA029973 HEK 293 Plasma membrane
Cell Junctions
Aggresome
HPA029973 U-2 OS Plasma membrane
Cell Junctions
Cytosol
HPA068407 CACO-2 Plasma membrane
Cell Junctions
HPA068407 SK-MEL-30 Cell Junctions
Cytosol
HPA068407 U-2 OS Plasma membrane
Cell Junctions

GENE INFORMATION

Gene name

 ABI1 (HGNC Symbol)

Synonyms

 ABI-1, E3B1, SSH3BP1

Description

 Abl-interactor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]

Chromosome

 10

Cytoband

 p12.1

Chromosome location (bp)

 26746593 - 26861087

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136754 (version 83.38)

Entrez gene

 10006

UniProt

 Q8IZP0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IZP0

Antibodypedia

 ABI1 antibodies

PROTEIN BROWSER
«
ABI1-001
ABI1-002
ABI1-003
ABI1-004
ABI1-005
ABI1-006
ABI1-007
ABI1-009
ABI1-201
ABI1-202
ABI1-203
ABI1-204
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABI1-001
ENSP00000365308
ENST00000376138
Q8IZP0 [Direct mapping]
Abl interactor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006928 [movement of cell or subcellular component]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008092 [cytoskeletal protein binding]
GO:0008154 [actin polymerization or depolymerization]
GO:0008285 [negative regulation of cell proliferation]
GO:0014069 [postsynaptic density]
GO:0016032 [viral process]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0031209 [SCAR complex]
GO:0032403 [protein complex binding]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0045211 [postsynaptic membrane]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 452 aa
49.4 kDa 		No 0
ABI1-002
ENSP00000365340
ENST00000376170
Q8IZP0 [Direct mapping]
Abl interactor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006928 [movement of cell or subcellular component]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008092 [cytoskeletal protein binding]
GO:0008154 [actin polymerization or depolymerization]
GO:0008285 [negative regulation of cell proliferation]
GO:0014069 [postsynaptic density]
GO:0016032 [viral process]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0031209 [SCAR complex]
GO:0032403 [protein complex binding]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0045211 [postsynaptic membrane]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 451 aa
49.3 kDa 		No 0
ABI1-003
ENSP00000365336
ENST00000376166
Q8IZP0 [Direct mapping]
Abl interactor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006928 [movement of cell or subcellular component]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008092 [cytoskeletal protein binding]
GO:0008154 [actin polymerization or depolymerization]
GO:0008285 [negative regulation of cell proliferation]
GO:0014069 [postsynaptic density]
GO:0016032 [viral process]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0031209 [SCAR complex]
GO:0032403 [protein complex binding]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0045211 [postsynaptic membrane]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 446 aa
48.7 kDa 		No 0
ABI1-004
ENSP00000365330
ENST00000376160
A0A0A0MRT6 [Direct mapping]
Abl interactor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0030296 [protein tyrosine kinase activator activity]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
Show all
 475 aa
51.8 kDa 		No 0
ABI1-005
ENSP00000365312
ENST00000376142
Q8IZP0 [Direct mapping]
Abl interactor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001756 [somitogenesis]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006928 [movement of cell or subcellular component]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008092 [cytoskeletal protein binding]
GO:0008154 [actin polymerization or depolymerization]
GO:0008285 [negative regulation of cell proliferation]
GO:0009987 [cellular process]
GO:0014069 [postsynaptic density]
GO:0016032 [viral process]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030175 [filopodium]
GO:0030296 [protein tyrosine kinase activator activity]
GO:0030426 [growth cone]
GO:0031209 [SCAR complex]
GO:0031252 [cell leading edge]
GO:0032403 [protein complex binding]
GO:0035855 [megakaryocyte development]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0043005 [neuron projection]
GO:0045087 [innate immune response]
GO:0045211 [postsynaptic membrane]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0072673 [lamellipodium morphogenesis]
Show all
 508 aa
55.1 kDa 		No 0
ABI1-006
ENSP00000365310
ENST00000376140
Q8IZP0 [Direct mapping]
Abl interactor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006928 [movement of cell or subcellular component]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008092 [cytoskeletal protein binding]
GO:0008154 [actin polymerization or depolymerization]
GO:0008285 [negative regulation of cell proliferation]
GO:0014069 [postsynaptic density]
GO:0016032 [viral process]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0031209 [SCAR complex]
GO:0032403 [protein complex binding]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0045211 [postsynaptic membrane]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 481 aa
52.5 kDa 		No 0
ABI1-007
ENSP00000352114
ENST00000359188
Q8IZP0 [Direct mapping]
Abl interactor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006928 [movement of cell or subcellular component]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008092 [cytoskeletal protein binding]
GO:0008154 [actin polymerization or depolymerization]
GO:0008285 [negative regulation of cell proliferation]
GO:0014069 [postsynaptic density]
GO:0016032 [viral process]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0031209 [SCAR complex]
GO:0032403 [protein complex binding]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0045211 [postsynaptic membrane]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 480 aa
52.4 kDa 		No 0
ABI1-009
ENSP00000365309
ENST00000376139
Q8IZP0 [Direct mapping]
Abl interactor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006928 [movement of cell or subcellular component]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008092 [cytoskeletal protein binding]
GO:0008154 [actin polymerization or depolymerization]
GO:0008285 [negative regulation of cell proliferation]
GO:0014069 [postsynaptic density]
GO:0016032 [viral process]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0031209 [SCAR complex]
GO:0032403 [protein complex binding]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0045211 [postsynaptic membrane]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 476 aa
51.8 kDa 		No 0
ABI1-201
ENSP00000279599
ENST00000346832
Q8IZP0 [Direct mapping]
Abl interactor 1
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006928 [movement of cell or subcellular component]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008092 [cytoskeletal protein binding]
GO:0008154 [actin polymerization or depolymerization]
GO:0008285 [negative regulation of cell proliferation]
GO:0014069 [postsynaptic density]
GO:0016032 [viral process]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0031209 [SCAR complex]
GO:0032403 [protein complex binding]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0045211 [postsynaptic membrane]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 496 aa
53.9 kDa 		No 0
ABI1-202
ENSP00000365307
ENST00000376137
Q8IZP0 [Direct mapping]
Abl interactor 1
B6VEX3 [Target identity:100%; Query identity:100%]
Abl-interactor 1 variant 41
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006928 [movement of cell or subcellular component]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008092 [cytoskeletal protein binding]
GO:0008154 [actin polymerization or depolymerization]
GO:0008285 [negative regulation of cell proliferation]
GO:0014069 [postsynaptic density]
GO:0016032 [viral process]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0031209 [SCAR complex]
GO:0032403 [protein complex binding]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0045211 [postsynaptic membrane]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 422 aa
46.4 kDa 		No 0
ABI1-203
ENSP00000440101
ENST00000490841
Q8IZP0 [Direct mapping]
Abl interactor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006928 [movement of cell or subcellular component]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008092 [cytoskeletal protein binding]
GO:0008154 [actin polymerization or depolymerization]
GO:0008285 [negative regulation of cell proliferation]
GO:0014069 [postsynaptic density]
GO:0016032 [viral process]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0031209 [SCAR complex]
GO:0032403 [protein complex binding]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0045211 [postsynaptic membrane]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 329 aa
35.9 kDa 		No 0
ABI1-204
ENSP00000439646
ENST00000536334
B6VEX4 [Direct mapping]
Abl interactor 1; Abl-interactor 1 variant 21
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0030296 [protein tyrosine kinase activator activity]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
Show all
 393 aa
43.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.