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Majority of cancer tissues showed moderate to strong membranous and occasional cytoplasmic staining. Gliomas, prostate and testis cancers along with several cases of carcinoids, renal, stomach and liver cancers were negative.
Several cases of lung and urothelial cancers along with a few cases of breast, ovarian, thyroid, cervical, gastric and pancreatic cancers showed weak to moderate cytoplasmic positivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
ANGPTL2 (HGNC Symbol)
Synonyms
ARP2, HARP
Description
Angiopoietin-like 2 (HGNC Symbol)
Entrez gene summary
Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. [provided by RefSeq, Jul 2008]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
