Expression of ZNF189 in cancer - Summary

CANCER ATLAS

Gene description

Zinc finger protein 189

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA034814

GENE INFORMATION
Gene name	ZNF189
Synonyms
Description	Zinc finger protein 189 (HGNC Symbol)
Entrez gene summary	Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 [PubMed 9653648]). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box (KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always present.[supplied by OMIM, May 2010]
Chromosome	9
Cytoband	q31.1
Chromosome location (bp)	101398873 - 101410660
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136870 (version 83.38)
Entrez gene	7743
UniProt	O75820 (UniProt - Evidence at protein level)
neXtProt	NX_O75820
Antibodypedia	ZNF189 antibodies

PROTEIN BROWSER

ZNF189-001	ZNF189-002	ZNF189-003	ZNF189-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZNF189-001 ENSP00000342019 ENST00000339664	O75820 [Direct mapping] Zinc finger protein 189 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002230 [positive regulation of defense response to virus by host] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	626 aa 73 kDa	No	0
ZNF189-002 ENSP00000363995 ENST00000374861	O75820 [Direct mapping] Zinc finger protein 189 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002230 [positive regulation of defense response to virus by host] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	612 aa 71.4 kDa	No	0
ZNF189-003 ENSP00000259395 ENST00000259395	O75820 [Direct mapping] Zinc finger protein 189 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002230 [positive regulation of defense response to virus by host] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	584 aa 68.2 kDa	No	0
ZNF189-201 ENSP00000483461 ENST00000615466	A0A087X0K2 [Direct mapping] Zinc finger protein 189 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	85 aa 9.6 kDa	No	0