Cell atlas - ZNF189 - The Human Protein Atlas

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ZNF189

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Intermediate filaments

Human cell
	Intermediate Filaments

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GENERAL INFORMATION
Gene name	ZNF189
Gene description	Zinc finger protein 189
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the intermediate filaments.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Intermediate filaments (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA034814
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the intermediate filaments.

Main location

Intermediate filaments (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA034814	U-2 OS	Intermediate filaments
	HPA034814	U-2 OS	Aggresome
	HPA034814	U-251 MG	Intermediate filaments

GENE INFORMATION
Gene name	ZNF189
Synonyms
Description	Zinc finger protein 189 (HGNC Symbol)
Entrez gene summary	Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 [PubMed 9653648]). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box (KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always present.[supplied by OMIM, May 2010]
Chromosome	9
Cytoband	q31.1
Chromosome location (bp)	101398873 - 101410660
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136870 (version 83.38)
Entrez gene	7743
UniProt	O75820 (UniProt - Evidence at protein level)
neXtProt	NX_O75820
Antibodypedia	ZNF189 antibodies

PROTEIN BROWSER

ZNF189-001	ZNF189-002	ZNF189-003	ZNF189-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZNF189-001 ENSP00000342019 ENST00000339664	O75820 [Direct mapping] Zinc finger protein 189 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002230 [positive regulation of defense response to virus by host] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	626 aa 73 kDa	No	0
ZNF189-002 ENSP00000363995 ENST00000374861	O75820 [Direct mapping] Zinc finger protein 189 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002230 [positive regulation of defense response to virus by host] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	612 aa 71.4 kDa	No	0
ZNF189-003 ENSP00000259395 ENST00000259395	O75820 [Direct mapping] Zinc finger protein 189 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002230 [positive regulation of defense response to virus by host] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	584 aa 68.2 kDa	No	0
ZNF189-201 ENSP00000483461 ENST00000615466	A0A087X0K2 [Direct mapping] Zinc finger protein 189 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	85 aa 9.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.