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ENPP2

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GENERAL INFORMATION

Gene name

 ENPP2

Gene description

 Ectonucleotide pyrophosphatase/phosphodiesterase 2

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus & the Golgi apparatus. In addition localized to the actin filaments.

RNA cell category

 Cell line enhanced (ASC TERT1, BJ hTERT+, AF22, U-2197)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (approved), Golgi apparatus (approved)

Additional location

 In addition localized to the Actin filaments (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA053652
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (ASC TERT1, BJ hTERT+, AF22, U-2197)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus & the Golgi apparatus. In addition localized to the actin filaments.

Main location

 Nucleus (approved), Golgi apparatus (approved)

Additional location

 Actin filaments (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA053652 BJ Nucleoplasm
Golgi apparatus
Actin filaments
HPA053652 HEK 293 Nucleus
Golgi apparatus
HPA053652 U-2 OS Nucleoplasm
Golgi apparatus

GENE INFORMATION

Gene name

 ENPP2 (HGNC Symbol)

Synonyms

 ATX, PD-IALPHA, PDNP2

Description

 Ectonucleotide pyrophosphatase/phosphodiesterase 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008]

Chromosome

 8

Cytoband

 q24.12

Chromosome location (bp)

 119557086 - 119673453

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136960 (version 83.38)

Entrez gene

 5168

UniProt

 Q13822 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13822

Antibodypedia

 ENPP2 antibodies

PROTEIN BROWSER
ENPP2-001
ENPP2-002
ENPP2-003
ENPP2-004
ENPP2-005
ENPP2-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ENPP2-001
ENSP00000403315
ENST00000427067
E7EUF1 [Direct mapping]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Show all
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003824 [catalytic activity]
GO:0004528 [phosphodiesterase I activity]
GO:0004551 [nucleotide diphosphatase activity]
GO:0004622 [lysophospholipase activity]
GO:0005044 [scavenger receptor activity]
GO:0006898 [receptor-mediated endocytosis]
GO:0006935 [chemotaxis]
GO:0006955 [immune response]
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
GO:0030247 [polysaccharide binding]
GO:0030334 [regulation of cell migration]
GO:0045765 [regulation of angiogenesis]
GO:0046872 [metal ion binding]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 884 aa
101.6 kDa 		No 0
ENPP2-002
ENSP00000075322
ENST00000075322
Q13822 [Direct mapping]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003824 [catalytic activity]
GO:0004528 [phosphodiesterase I activity]
GO:0004551 [nucleotide diphosphatase activity]
GO:0004622 [lysophospholipase activity]
GO:0005044 [scavenger receptor activity]
GO:0005509 [calcium ion binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006796 [phosphate-containing compound metabolic process]
GO:0006898 [receptor-mediated endocytosis]
GO:0006928 [movement of cell or subcellular component]
GO:0006935 [chemotaxis]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008134 [transcription factor binding]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0009395 [phospholipid catabolic process]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0016787 [hydrolase activity]
GO:0030247 [polysaccharide binding]
GO:0030334 [regulation of cell migration]
GO:0034638 [phosphatidylcholine catabolic process]
GO:0045765 [regulation of angiogenesis]
GO:0046872 [metal ion binding]
GO:0047391 [alkylglycerophosphoethanolamine phosphodiesterase activity]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
Show all
 863 aa
99 kDa 		No 1
ENPP2-003
ENSP00000259486
ENST00000259486
Q13822 [Direct mapping]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003824 [catalytic activity]
GO:0004528 [phosphodiesterase I activity]
GO:0004551 [nucleotide diphosphatase activity]
GO:0004622 [lysophospholipase activity]
GO:0005044 [scavenger receptor activity]
GO:0005509 [calcium ion binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006796 [phosphate-containing compound metabolic process]
GO:0006898 [receptor-mediated endocytosis]
GO:0006928 [movement of cell or subcellular component]
GO:0006935 [chemotaxis]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008134 [transcription factor binding]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0009395 [phospholipid catabolic process]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0016787 [hydrolase activity]
GO:0030247 [polysaccharide binding]
GO:0030334 [regulation of cell migration]
GO:0034638 [phosphatidylcholine catabolic process]
GO:0045765 [regulation of angiogenesis]
GO:0046872 [metal ion binding]
GO:0047391 [alkylglycerophosphoethanolamine phosphodiesterase activity]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
Show all
 915 aa
105.2 kDa 		No 1
ENPP2-004
ENSP00000428291
ENST00000522826
Q13822 [Direct mapping]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003824 [catalytic activity]
GO:0004528 [phosphodiesterase I activity]
GO:0004551 [nucleotide diphosphatase activity]
GO:0004622 [lysophospholipase activity]
GO:0005044 [scavenger receptor activity]
GO:0005509 [calcium ion binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006796 [phosphate-containing compound metabolic process]
GO:0006898 [receptor-mediated endocytosis]
GO:0006928 [movement of cell or subcellular component]
GO:0006935 [chemotaxis]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008134 [transcription factor binding]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0009395 [phospholipid catabolic process]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0016787 [hydrolase activity]
GO:0030247 [polysaccharide binding]
GO:0030334 [regulation of cell migration]
GO:0034638 [phosphatidylcholine catabolic process]
GO:0045765 [regulation of angiogenesis]
GO:0046872 [metal ion binding]
GO:0047391 [alkylglycerophosphoethanolamine phosphodiesterase activity]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
Show all
 888 aa
102 kDa 		No 1
ENPP2-005
ENSP00000429476
ENST00000522167
E5RIA2 [Direct mapping]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003824 [catalytic activity]
GO:0004528 [phosphodiesterase I activity]
GO:0004551 [nucleotide diphosphatase activity]
GO:0004622 [lysophospholipase activity]
GO:0006935 [chemotaxis]
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
GO:0030334 [regulation of cell migration]
GO:0045765 [regulation of angiogenesis]
GO:0046872 [metal ion binding]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 498 aa
57.7 kDa 		No 0
ENPP2-008
ENSP00000428304
ENST00000520066
E5RJ49 [Direct mapping]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004528 [phosphodiesterase I activity]
GO:0004551 [nucleotide diphosphatase activity]
GO:0004622 [lysophospholipase activity]
GO:0005044 [scavenger receptor activity]
GO:0006898 [receptor-mediated endocytosis]
GO:0006935 [chemotaxis]
GO:0006955 [immune response]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0030247 [polysaccharide binding]
GO:0030334 [regulation of cell migration]
GO:0045765 [regulation of angiogenesis]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 245 aa
27.5 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.