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DERL1

CANCER ATLAS

Gene description

 Derlin 1

Protein class

 Plasma proteins, Predicted membrane proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA016562
CAB037269

GENE INFORMATION

Gene name

 DERL1 (HGNC Symbol)

Synonyms

 DER-1, DER1, derlin-1, FLJ13784, MGC3067, PRO2577

Description

 Derlin 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

Chromosome

 8

Cytoband

 q24.13

Chromosome location (bp)

 123013164 - 123042423

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136986 (version 83.38)

Entrez gene

 79139

UniProt

 Q9BUN8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BUN8

Antibodypedia

 DERL1 antibodies

PROTEIN BROWSER
DERL1-001
DERL1-002
DERL1-004
DERL1-005
DERL1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DERL1-001
ENSP00000259512
ENST00000259512
Q9BUN8 [Direct mapping]
Derlin-1
A0A024R9G3 [Target identity:100%; Query identity:100%]
Der1-like domain family, member 1, isoform CRA_a
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005783 [endoplasmic reticulum]
GO:0006986 [response to unfolded protein]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019060 [intracellular transport of viral protein in host cell]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0030970 [retrograde protein transport, ER to cytosol]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031648 [protein destabilization]
GO:0032092 [positive regulation of protein binding]
GO:0034098 [VCP-NPL4-UFD1 AAA ATPase complex]
GO:0034620 [cellular response to unfolded protein]
GO:0036502 [Derlin-1-VIMP complex]
GO:0036503 [ERAD pathway]
GO:0036513 [Derlin-1 retrotranslocation complex]
GO:0042288 [MHC class I protein binding]
GO:0043657 [host cell]
GO:0045184 [establishment of protein localization]
GO:0051117 [ATPase binding]
GO:0051260 [protein homooligomerization]
GO:0071712 [ER-associated misfolded protein catabolic process]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 251 aa
28.8 kDa 		No 4
DERL1-002
ENSP00000389965
ENST00000419562
B4E1G1 [Direct mapping]
Derlin-1; cDNA FLJ57771, highly similar to Derlin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005783 [endoplasmic reticulum]
GO:0016021 [integral component of membrane]
Show all
 151 aa
17 kDa 		No 2
DERL1-004
ENSP00000384289
ENST00000405944
Q9BUN8 [Direct mapping]
Derlin-1
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0006986 [response to unfolded protein]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019060 [intracellular transport of viral protein in host cell]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0030970 [retrograde protein transport, ER to cytosol]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031648 [protein destabilization]
GO:0032092 [positive regulation of protein binding]
GO:0034098 [VCP-NPL4-UFD1 AAA ATPase complex]
GO:0036502 [Derlin-1-VIMP complex]
GO:0036503 [ERAD pathway]
GO:0036513 [Derlin-1 retrotranslocation complex]
GO:0042288 [MHC class I protein binding]
GO:0043657 [host cell]
GO:0045184 [establishment of protein localization]
GO:0051117 [ATPase binding]
GO:0051260 [protein homooligomerization]
GO:0071712 [ER-associated misfolded protein catabolic process]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 231 aa
26.4 kDa 		No 4
DERL1-005
ENSP00000429199
ENST00000523036
E5RGY0 [Direct mapping]
Derlin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005783 [endoplasmic reticulum]
GO:0016021 [integral component of membrane]
Show all
 151 aa
17.2 kDa 		No 2
DERL1-006
ENSP00000430086
ENST00000519018
E5RGY0 [Direct mapping]
Derlin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005783 [endoplasmic reticulum]
GO:0016021 [integral component of membrane]
Show all
 151 aa
17.2 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.