Cell atlas - DERL1 - The Human Protein Atlas

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DERL1

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	DERL1
Gene description	Derlin 1
Protein class	Plasma proteins Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (validated)

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA016562
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA016562	A-431	Endoplasmic reticulum
	HPA016562	U-2 OS	Endoplasmic reticulum
	HPA016562	U-251 MG	Endoplasmic reticulum

GENE INFORMATION
Gene name	DERL1 (HGNC Symbol)
Synonyms	DER-1, DER1, derlin-1, FLJ13784, MGC3067, PRO2577
Description	Derlin 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Chromosome	8
Cytoband	q24.13
Chromosome location (bp)	123013164 - 123042423
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136986 (version 83.38)
Entrez gene	79139
UniProt	Q9BUN8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BUN8
Antibodypedia	DERL1 antibodies

PROTEIN BROWSER

DERL1-001	DERL1-002	DERL1-004	DERL1-005	DERL1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DERL1-001 ENSP00000259512 ENST00000259512	Q9BUN8 [Direct mapping] Derlin-1 A0A024R9G3 [Target identity:100%; Query identity:100%] Der1-like domain family, member 1, isoform CRA_a Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005783 [endoplasmic reticulum] GO:0006986 [response to unfolded protein] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019060 [intracellular transport of viral protein in host cell] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0030970 [retrograde protein transport, ER to cytosol] GO:0031398 [positive regulation of protein ubiquitination] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032092 [positive regulation of protein binding] GO:0034098 [VCP-NPL4-UFD1 AAA ATPase complex] GO:0034620 [cellular response to unfolded protein] GO:0036502 [Derlin-1-VIMP complex] GO:0036503 [ERAD pathway] GO:0036513 [Derlin-1 retrotranslocation complex] GO:0042288 [MHC class I protein binding] GO:0043657 [host cell] GO:0045184 [establishment of protein localization] GO:0051117 [ATPase binding] GO:0051260 [protein homooligomerization] GO:0071712 [ER-associated misfolded protein catabolic process] GO:1990381 [ubiquitin-specific protease binding] Show all	251 aa 28.8 kDa	No	4
DERL1-002 ENSP00000389965 ENST00000419562	B4E1G1 [Direct mapping] Derlin-1; cDNA FLJ57771, highly similar to Derlin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] Show all	151 aa 17 kDa	No	2
DERL1-004 ENSP00000384289 ENST00000405944	Q9BUN8 [Direct mapping] Derlin-1 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0006986 [response to unfolded protein] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019060 [intracellular transport of viral protein in host cell] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0030970 [retrograde protein transport, ER to cytosol] GO:0031398 [positive regulation of protein ubiquitination] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032092 [positive regulation of protein binding] GO:0034098 [VCP-NPL4-UFD1 AAA ATPase complex] GO:0036502 [Derlin-1-VIMP complex] GO:0036503 [ERAD pathway] GO:0036513 [Derlin-1 retrotranslocation complex] GO:0042288 [MHC class I protein binding] GO:0043657 [host cell] GO:0045184 [establishment of protein localization] GO:0051117 [ATPase binding] GO:0051260 [protein homooligomerization] GO:0071712 [ER-associated misfolded protein catabolic process] GO:1990381 [ubiquitin-specific protease binding] Show all	231 aa 26.4 kDa	No	4
DERL1-005 ENSP00000429199 ENST00000523036	E5RGY0 [Direct mapping] Derlin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] Show all	151 aa 17.2 kDa	No	2
DERL1-006 ENSP00000430086 ENST00000519018	E5RGY0 [Direct mapping] Derlin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] Show all	151 aa 17.2 kDa	No	2

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.