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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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NOV
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

NOV

Gene description

Nephroblastoma overexpressed

Protein class

Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (adrenal gland)
GTEx:Tissue enriched (adrenal gland)
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in adrenal gland.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA019684 , CAB034423
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adrenal gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

NOV (HGNC Symbol)

Synonyms

CCN3, IGFBP9

Description

Nephroblastoma overexpressed (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009]

Chromosome

8

Cytoband

q24.12

Chromosome location (bp)

119416306 - 119424353

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136999 (version 83.38)

Entrez gene

4856

UniProt

P48745 (UniProt - Evidence at protein level)

neXtProt

NX_P48745

Antibodypedia

NOV antibodies

PROTEIN BROWSER

NOV-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NOV-001
ENSP00000259526
ENST00000259526
P48745 [Direct mapping]
Protein NOV homolog
A0A024R9J4 [Target identity:100%; Query identity:100%]
Nephroblastoma overexpressed gene, isoform CRA_a
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   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001558 [regulation of cell growth]
GO:0002062 [chondrocyte differentiation]
GO:0005112 [Notch binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005737 [cytoplasm]
GO:0005921 [gap junction]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0010468 [regulation of gene expression]
GO:0010761 [fibroblast migration]
GO:0010832 [negative regulation of myotube differentiation]
GO:0014909 [smooth muscle cell migration]
GO:0030308 [negative regulation of cell growth]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031012 [extracellular matrix]
GO:0033627 [cell adhesion mediated by integrin]
GO:0035767 [endothelial cell chemotaxis]
GO:0042347 [negative regulation of NF-kappaB import into nucleus]
GO:0043025 [neuronal cell body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044342 [type B pancreatic cell proliferation]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0046676 [negative regulation of insulin secretion]
GO:0048659 [smooth muscle cell proliferation]
GO:0050728 [negative regulation of inflammatory response]
GO:0060326 [cell chemotaxis]
GO:0060392 [negative regulation of SMAD protein import into nucleus]
GO:0060548 [negative regulation of cell death]
GO:0061484 [hematopoietic stem cell homeostasis]
GO:0071603 [endothelial cell-cell adhesion]
GO:0090027 [negative regulation of monocyte chemotaxis]
GO:1902731 [negative regulation of chondrocyte proliferation]
GO:1904057 [negative regulation of sensory perception of pain]
GO:1990523 [bone regeneration]
Show all
357 aa
39.2 kDa
Yes 0

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