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A few cases of prostate cancers showed weak cytoplasmic staining. Remaining malignant cells were negative.
GENE INFORMATION
Gene name
DMRT1 (HGNC Symbol)
Synonyms
CT154, DMT1
Description
Doublesex and mab-3 related transcription factor 1 (HGNC Symbol)
Entrez gene summary
This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. [provided by RefSeq, Jul 2008]