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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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DMRT1
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

DMRT1

Gene description

Doublesex and mab-3 related transcription factor 1

Protein class

Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression

Nuclear expression in a subset spermatogonia.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Supported based on 1 antibody.
HPA027850
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

DMRT1 (HGNC Symbol)

Synonyms

CT154, DMT1

Description

Doublesex and mab-3 related transcription factor 1 (HGNC Symbol)

Entrez gene summary

This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

p24.3

Chromosome location (bp)

841690 - 969090

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137090 (version 83.38)

Entrez gene

1761

UniProt

Q9Y5R6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y5R6

Antibodypedia

DMRT1 antibodies

PROTEIN BROWSER

DMRT1-001
DMRT1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DMRT1-001
ENSP00000371711
ENST00000382276
Q9Y5R6 [Direct mapping]
Doublesex- and mab-3-related transcription factor 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000902 [cell morphogenesis]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002176 [male germ cell proliferation]
GO:0003006 [developmental process involved in reproduction]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007283 [spermatogenesis]
GO:0007548 [sex differentiation]
GO:0008354 [germ cell migration]
GO:0008584 [male gonad development]
GO:0030238 [male sex determination]
GO:0035556 [intracellular signal transduction]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045835 [negative regulation of meiotic nuclear division]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046661 [male sex differentiation]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048599 [oocyte development]
GO:0060008 [Sertoli cell differentiation]
GO:0060009 [Sertoli cell development]
GO:0060903 [positive regulation of meiosis I]
GO:1900107 [regulation of nodal signaling pathway]
GO:2000020 [positive regulation of male gonad development]
Show all
373 aa
39.5 kDa
No 0
DMRT1-002
ENSP00000454701
ENST00000569227
H3BN61 [Direct mapping]
Doublesex- and mab-3-related transcription factor 1
Show all
Predicted intracellular proteins
Show all
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0002176 [male germ cell proliferation]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007548 [sex differentiation]
GO:0042803 [protein homodimerization activity]
GO:0045835 [negative regulation of meiotic nuclear division]
GO:0046982 [protein heterodimerization activity]
GO:0048599 [oocyte development]
GO:0060903 [positive regulation of meiosis I]
Show all
215 aa
23.2 kDa
No 0

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