Expression of GMPR in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Guanosine monophosphate reductase

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA000904	HPA021476

GENE INFORMATION
Gene name	GMPR
Synonyms
Description	Guanosine monophosphate reductase (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides.[provided by RefSeq, Oct 2009]
Chromosome	6
Cytoband	p22.3
Chromosome location (bp)	16238580 - 16295549
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137198 (version 83.38)
Entrez gene	2766
UniProt	P36959 (UniProt - Evidence at protein level)
neXtProt	NX_P36959
Antibodypedia	GMPR antibodies

PROTEIN BROWSER

GMPR-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GMPR-001 ENSP00000259727 ENST00000259727	P36959 [Direct mapping] GMP reductase 1 Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003920 [GMP reductase activity] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0009117 [nucleotide metabolic process] GO:0009409 [response to cold] GO:0016491 [oxidoreductase activity] GO:0043101 [purine-containing compound salvage] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:1902560 [GMP reductase complex] Show all	345 aa 37.4 kDa	No	0