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GMPR

GENERAL INFORMATION

Gene name

 GMPR

Gene description

 Guanosine monophosphate reductase

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues including endocrine glands, respiratory epithelia, stomach and breast.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA000904 , HPA021476
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Bronchus

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GMPR

Synonyms

Description

 Guanosine monophosphate reductase (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides.[provided by RefSeq, Oct 2009]

Chromosome

 6

Cytoband

 p22.3

Chromosome location (bp)

 16238580 - 16295549

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137198 (version 83.38)

Entrez gene

 2766

UniProt

 P36959 (UniProt - Evidence at protein level)

neXtProt

 NX_P36959

Antibodypedia

 GMPR antibodies

PROTEIN BROWSER
GMPR-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GMPR-001
ENSP00000259727
ENST00000259727
P36959 [Direct mapping]
GMP reductase 1
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0003920 [GMP reductase activity]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0009117 [nucleotide metabolic process]
GO:0009409 [response to cold]
GO:0016491 [oxidoreductase activity]
GO:0043101 [purine-containing compound salvage]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:1902560 [GMP reductase complex]
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 345 aa
37.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.