Expression of FRS3 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Fibroblast growth factor receptor substrate 3

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA030162	HPA030174

GENE INFORMATION
Gene name	FRS3 (HGNC Symbol)
Synonyms	FRS2B, FRS2beta, SNT-2
Description	Fibroblast growth factor receptor substrate 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	41770176 - 41786542
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137218 (version 83.38)
Entrez gene	10817
UniProt	O43559 (UniProt - Evidence at protein level)
neXtProt	NX_O43559
Antibodypedia	FRS3 antibodies

PROTEIN BROWSER

FRS3-001	FRS3-004	FRS3-005	FRS3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FRS3-001 ENSP00000362109 ENST00000373018	O43559 [Direct mapping] Fibroblast growth factor receptor substrate 3 Show all	Predicted intracellular proteins Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0005104 [fibroblast growth factor receptor binding] GO:0005158 [insulin receptor binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0045087 [innate immune response] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	492 aa 54.5 kDa	No	0
FRS3-004 ENSP00000396715 ENST00000426290	A0A0A0MSM8 [Direct mapping] Fibroblast growth factor receptor substrate 3 Show all	Predicted intracellular proteins Show all	GO:0005158 [insulin receptor binding] Show all	147 aa 16.6 kDa	No	0
FRS3-005 ENSP00000413214 ENST00000422888	A6PVU0 [Direct mapping] Fibroblast growth factor receptor substrate 3 Show all	Predicted intracellular proteins Show all		36 aa 3.8 kDa	No	0
FRS3-201 ENSP00000259748 ENST00000259748	O43559 [Direct mapping] Fibroblast growth factor receptor substrate 3 Show all	Predicted intracellular proteins Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0005104 [fibroblast growth factor receptor binding] GO:0005158 [insulin receptor binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0045087 [innate immune response] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	492 aa 54.5 kDa	No	0