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FRS3

GENERAL INFORMATION

Gene name

 FRS3

Gene description

 Fibroblast growth factor receptor substrate 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic and membranous expression in basal cells of squamous epithelia, epididymis and prostate.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA030162 , HPA030174
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FRS3 (HGNC Symbol)

Synonyms

 FRS2B, FRS2beta, SNT-2

Description

 Fibroblast growth factor receptor substrate 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]

Chromosome

 6

Cytoband

 p21.1

Chromosome location (bp)

 41770176 - 41786542

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137218 (version 83.38)

Entrez gene

 10817

UniProt

 O43559 (UniProt - Evidence at protein level)

neXtProt

 NX_O43559

Antibodypedia

 FRS3 antibodies

PROTEIN BROWSER
FRS3-001
FRS3-004
FRS3-005
FRS3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FRS3-001
ENSP00000362109
ENST00000373018
O43559 [Direct mapping]
Fibroblast growth factor receptor substrate 3
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Predicted intracellular proteins
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 492 aa
54.5 kDa 		No 0
FRS3-004
ENSP00000396715
ENST00000426290
A0A0A0MSM8 [Direct mapping]
Fibroblast growth factor receptor substrate 3
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Predicted intracellular proteins
Show all
GO:0005158 [insulin receptor binding]
Show all
 147 aa
16.6 kDa 		No 0
FRS3-005
ENSP00000413214
ENST00000422888
A6PVU0 [Direct mapping]
Fibroblast growth factor receptor substrate 3
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Predicted intracellular proteins
Show all
 36 aa
3.8 kDa 		No 0
FRS3-201
ENSP00000259748
ENST00000259748
O43559 [Direct mapping]
Fibroblast growth factor receptor substrate 3
Show all
Predicted intracellular proteins
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 492 aa
54.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.