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Few cases of ovarian, urothelial, colorectal, lung, endometrial, cervical cancers showed weak to moderate cytoplasmic positivity. Few squamous cell carcinomas of skin cancers displayed additional nuclear staining. Other cancers tissues were in general negative.
A few cases of pancreatic cancers displayed moderate cytoplasmic staining. Tumor cells in general were negative.
GENE INFORMATION
Gene name
CAPN11
Synonyms
Description
Calpain 11 (HGNC Symbol)
Entrez gene summary
Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008]
