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CAPN11

GENERAL INFORMATION

Gene name

 CAPN11

Gene description

 Calpain 11

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA030955 , CAB018070
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Ovary

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 CAPN11

Synonyms

Description

 Calpain 11 (HGNC Symbol)

Entrez gene summary

 Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008]

Chromosome

 6

Cytoband

 p21.1

Chromosome location (bp)

 44158811 - 44184402

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137225 (version 83.38)

Entrez gene

 11131

UniProt

 Q9UMQ6 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UMQ6

Antibodypedia

 CAPN11 antibodies

PROTEIN BROWSER
CAPN11-001
CAPN11-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CAPN11-001
ENSP00000381758
ENST00000398776
Q9UMQ6 [Direct mapping]
Calpain-11
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Enzymes
   Peptidases
   Cysteine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0001669 [acrosomal vesicle]
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
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 739 aa
84.4 kDa 		No 0
CAPN11-005
ENSP00000432420
ENST00000532171
E9PQZ4 [Direct mapping]
Calpain-11
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Predicted intracellular proteins
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
Show all
 182 aa
19.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.