Expression of TUBB2B in cancer - Summary

CANCER ATLAS

Gene description

Tubulin, beta 2B class IIb

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA043640	HPA046280

GENE INFORMATION
Gene name	TUBB2B (HGNC Symbol)
Synonyms	bA506K6.1, DKFZp566F223, MGC8685
Description	Tubulin, beta 2B class IIb (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010]
Chromosome	6
Cytoband	p25.2
Chromosome location (bp)	3224261 - 3231730
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137285 (version 83.38)
Entrez gene	347733
UniProt	Q9BVA1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BVA1
Antibodypedia	TUBB2B antibodies

PROTEIN BROWSER

TUBB2B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TUBB2B-001 ENSP00000259818 ENST00000259818	Q9BVA1 [Direct mapping] Tubulin beta-2B chain Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001764 [neuron migration] GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0006457 [protein folding] GO:0007017 [microtubule-based process] GO:0043234 [protein complex] GO:0044267 [cellular protein metabolic process] GO:0051084 ['de novo' posttranslational protein folding] GO:0051258 [protein polymerization] Show all	445 aa 50 kDa	No	0