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TUBB2B

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GENERAL INFORMATION

Gene name

 TUBB2B

Gene description

 Tubulin, beta 2B class IIb

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the microtubules. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Cell line enhanced (SCLC-21H, AF22, SH-SY5Y, CACO-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Microtubules (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA043640
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, AF22, SH-SY5Y, CACO-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the microtubules. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Microtubules (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA043640 A-431 Microtubules
HPA043640 U-2 OS Microtubules
HPA043640 U-251 MG Microtubules

GENE INFORMATION

Gene name

 TUBB2B (HGNC Symbol)

Synonyms

 bA506K6.1, DKFZp566F223, MGC8685

Description

 Tubulin, beta 2B class IIb (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010]

Chromosome

 6

Cytoband

 p25.2

Chromosome location (bp)

 3224261 - 3231730

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137285 (version 83.38)

Entrez gene

 347733

UniProt

 Q9BVA1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BVA1

Antibodypedia

 TUBB2B antibodies

PROTEIN BROWSER
TUBB2B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TUBB2B-001
ENSP00000259818
ENST00000259818
Q9BVA1 [Direct mapping]
Tubulin beta-2B chain
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001764 [neuron migration]
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0007017 [microtubule-based process]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051258 [protein polymerization]
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 445 aa
50 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.