Expression of UQCC2 in cancer - Summary

CANCER ATLAS

Gene description

Ubiquinol-cytochrome c reductase complex assembly factor 2

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA039111

GENE INFORMATION
Gene name	UQCC2 (HGNC Symbol)
Synonyms	bA6B20.2, C6orf125, Cbp6, M19, MGC14833, MNF1
Description	Ubiquinol-cytochrome c reductase complex assembly factor 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a nucleoid protein localized to the mitochondria inner membrane. The encoded protein affects regulation of insulin secretion, mitochondrial ATP production, and myogenesis through modulation of mitochondrial respiratory chain activity. [provided by RefSeq, Oct 2012]
Chromosome	6
Cytoband	p21.31
Chromosome location (bp)	33694293 - 33711727
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137288 (version 83.38)
Entrez gene	84300
UniProt	Q9BRT2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BRT2
Antibodypedia	UQCC2 antibodies

PROTEIN BROWSER

UQCC2-001	UQCC2-002	UQCC2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UQCC2-001 ENSP00000476140 ENST00000607484	Q9BRT2 [Direct mapping] Ubiquinol-cytochrome-c reductase complex assembly factor 2 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002082 [regulation of oxidative phosphorylation] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005758 [mitochondrial intermembrane space] GO:0005759 [mitochondrial matrix] GO:0034551 [mitochondrial respiratory chain complex III assembly] GO:0042645 [mitochondrial nucleoid] GO:0050796 [regulation of insulin secretion] GO:0070131 [positive regulation of mitochondrial translation] GO:1903364 [positive regulation of cellular protein catabolic process] GO:2001014 [regulation of skeletal muscle cell differentiation] Show all	126 aa 14.9 kDa	No	0
UQCC2-002 ENSP00000363331 ENST00000374214	Q5TAQ0 [Direct mapping] Ubiquinol-cytochrome-c reductase complex assembly factor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005739 [mitochondrion] Show all	101 aa 11.9 kDa	No	0
UQCC2-004 ENSP00000363348 ENST00000374231	V5IRT4 [Direct mapping] Ubiquinol-cytochrome-c reductase complex assembly factor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		126 aa 14.7 kDa	No	0