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UQCC2

GENERAL INFORMATION

Gene name

 UQCC2

Gene description

 Ubiquinol-cytochrome c reductase complex assembly factor 2

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA039111
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Appendix
N/A
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 UQCC2 (HGNC Symbol)

Synonyms

 bA6B20.2, C6orf125, Cbp6, M19, MGC14833, MNF1

Description

 Ubiquinol-cytochrome c reductase complex assembly factor 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a nucleoid protein localized to the mitochondria inner membrane. The encoded protein affects regulation of insulin secretion, mitochondrial ATP production, and myogenesis through modulation of mitochondrial respiratory chain activity. [provided by RefSeq, Oct 2012]

Chromosome

 6

Cytoband

 p21.31

Chromosome location (bp)

 33694293 - 33711727

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137288 (version 83.38)

Entrez gene

 84300

UniProt

 Q9BRT2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BRT2

Antibodypedia

 UQCC2 antibodies

PROTEIN BROWSER
UQCC2-001
UQCC2-002
UQCC2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UQCC2-001
ENSP00000476140
ENST00000607484
Q9BRT2 [Direct mapping]
Ubiquinol-cytochrome-c reductase complex assembly factor 2
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002082 [regulation of oxidative phosphorylation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005759 [mitochondrial matrix]
GO:0034551 [mitochondrial respiratory chain complex III assembly]
GO:0042645 [mitochondrial nucleoid]
GO:0050796 [regulation of insulin secretion]
GO:0070131 [positive regulation of mitochondrial translation]
GO:1903364 [positive regulation of cellular protein catabolic process]
GO:2001014 [regulation of skeletal muscle cell differentiation]
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 126 aa
14.9 kDa 		No 0
UQCC2-002
ENSP00000363331
ENST00000374214
Q5TAQ0 [Direct mapping]
Ubiquinol-cytochrome-c reductase complex assembly factor 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
Show all
 101 aa
11.9 kDa 		No 0
UQCC2-004
ENSP00000363348
ENST00000374231
V5IRT4 [Direct mapping]
Ubiquinol-cytochrome-c reductase complex assembly factor 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 126 aa
14.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.