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TAF8

CANCER ATLAS

Gene description

 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA031730
HPA031731
HPA031734

GENE INFORMATION

Gene name

 TAF8 (HGNC Symbol)

Synonyms

 FLJ32821, TAF(II)43, TBN

Description

 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p21.1

Chromosome location (bp)

 42050513 - 42087461

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137413 (version 83.38)

Entrez gene

 129685

UniProt

 Q7Z7C8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7Z7C8

Antibodypedia

 TAF8 antibodies

PROTEIN BROWSER
TAF8-001
TAF8-002
TAF8-003
TAF8-004
TAF8-005
TAF8-007
TAF8-009
TAF8-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TAF8-001
ENSP00000362073
ENST00000372982
Q7Z7C8 [Direct mapping]
Transcription initiation factor TFIID subunit 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005669 [transcription factor TFIID complex]
GO:0006351 [transcription, DNA-templated]
GO:0030154 [cell differentiation]
GO:0045598 [regulation of fat cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051457 [maintenance of protein location in nucleus]
Show all
 338 aa
37.4 kDa 		No 0
TAF8-002
ENSP00000362069
ENST00000372978
A0A0A0MRR3 [Direct mapping]
Transcription initiation factor TFIID subunit 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046982 [protein heterodimerization activity]
Show all
 174 aa
18.7 kDa 		No 0
TAF8-003
ENSP00000411900
ENST00000456846
Q7Z7C8 [Direct mapping]
Transcription initiation factor TFIID subunit 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005669 [transcription factor TFIID complex]
GO:0006351 [transcription, DNA-templated]
GO:0030154 [cell differentiation]
GO:0045598 [regulation of fat cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051457 [maintenance of protein location in nucleus]
Show all
 311 aa
34.4 kDa 		No 0
TAF8-004
ENSP00000362068
ENST00000372977
Q7Z7C8 [Direct mapping]
Transcription initiation factor TFIID subunit 8
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001833 [inner cell mass cell proliferation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005669 [transcription factor TFIID complex]
GO:0006351 [transcription, DNA-templated]
GO:0030154 [cell differentiation]
GO:0045598 [regulation of fat cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051457 [maintenance of protein location in nucleus]
Show all
 310 aa
34.3 kDa 		No 0
TAF8-005
ENSP00000417867
ENST00000494547
Q7Z7C8 [Direct mapping]
Transcription initiation factor TFIID subunit 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005669 [transcription factor TFIID complex]
GO:0006351 [transcription, DNA-templated]
GO:0030154 [cell differentiation]
GO:0045598 [regulation of fat cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051457 [maintenance of protein location in nucleus]
Show all
 338 aa
37.4 kDa 		No 0
TAF8-007
ENSP00000418029
ENST00000465926
B4DZU5 [Direct mapping]
Transcription initiation factor TFIID subunit 8; cDNA FLJ57866, highly similar to Homo sapiens TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, mRNA
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
Show all
 234 aa
26.4 kDa 		No 0
TAF8-009
ENSP00000417760
ENST00000472818
C9J7M8 [Direct mapping]
Transcription initiation factor TFIID subunit 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0046982 [protein heterodimerization activity]
Show all
 123 aa
13.2 kDa 		No 0
TAF8-010
ENSP00000417738
ENST00000482432
C9J856 [Direct mapping]
Transcription initiation factor TFIID subunit 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 60 aa
6.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.