Cell atlas - TAF8 - The Human Protein Atlas

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TAF8

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TAF8
Gene description	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (validated)

DATA RELIABILITY
Reliability score	Validated based on 3 antibodies. HPA031730 , HPA031731 , HPA031734
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus.

Main location

Nucleus (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA031730	A-431	Nucleoplasm
	HPA031730	U-2 OS	Nucleus
	HPA031730	U-251 MG	Nucleoplasm
	HPA031731	A-431	Nucleoplasm
	HPA031731	U-2 OS	No staining
	HPA031731	U-251 MG	Nucleoplasm
	HPA031734	A-431	Nucleoplasm
	HPA031734	U-2 OS	Nucleoplasm
	HPA031734	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	TAF8 (HGNC Symbol)
Synonyms	FLJ32821, TAF(II)43, TBN
Description	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa (HGNC Symbol)
Entrez gene summary	This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	42050513 - 42087461
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137413 (version 83.38)
Entrez gene	129685
UniProt	Q7Z7C8 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z7C8
Antibodypedia	TAF8 antibodies

PROTEIN BROWSER

TAF8-001	TAF8-002	TAF8-003	TAF8-004	TAF8-005	TAF8-007	TAF8-009	TAF8-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TAF8-001 ENSP00000362073 ENST00000372982	Q7Z7C8 [Direct mapping] Transcription initiation factor TFIID subunit 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005669 [transcription factor TFIID complex] GO:0006351 [transcription, DNA-templated] GO:0030154 [cell differentiation] GO:0045598 [regulation of fat cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046982 [protein heterodimerization activity] GO:0048471 [perinuclear region of cytoplasm] GO:0051457 [maintenance of protein location in nucleus] Show all	338 aa 37.4 kDa	No	0
TAF8-002 ENSP00000362069 ENST00000372978	A0A0A0MRR3 [Direct mapping] Transcription initiation factor TFIID subunit 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046982 [protein heterodimerization activity] Show all	174 aa 18.7 kDa	No	0
TAF8-003 ENSP00000411900 ENST00000456846	Q7Z7C8 [Direct mapping] Transcription initiation factor TFIID subunit 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005669 [transcription factor TFIID complex] GO:0006351 [transcription, DNA-templated] GO:0030154 [cell differentiation] GO:0045598 [regulation of fat cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046982 [protein heterodimerization activity] GO:0048471 [perinuclear region of cytoplasm] GO:0051457 [maintenance of protein location in nucleus] Show all	311 aa 34.4 kDa	No	0
TAF8-004 ENSP00000362068 ENST00000372977	Q7Z7C8 [Direct mapping] Transcription initiation factor TFIID subunit 8 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001833 [inner cell mass cell proliferation] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005669 [transcription factor TFIID complex] GO:0006351 [transcription, DNA-templated] GO:0030154 [cell differentiation] GO:0045598 [regulation of fat cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046982 [protein heterodimerization activity] GO:0048471 [perinuclear region of cytoplasm] GO:0051457 [maintenance of protein location in nucleus] Show all	310 aa 34.3 kDa	No	0
TAF8-005 ENSP00000417867 ENST00000494547	Q7Z7C8 [Direct mapping] Transcription initiation factor TFIID subunit 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005669 [transcription factor TFIID complex] GO:0006351 [transcription, DNA-templated] GO:0030154 [cell differentiation] GO:0045598 [regulation of fat cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046982 [protein heterodimerization activity] GO:0048471 [perinuclear region of cytoplasm] GO:0051457 [maintenance of protein location in nucleus] Show all	338 aa 37.4 kDa	No	0
TAF8-007 ENSP00000418029 ENST00000465926	B4DZU5 [Direct mapping] Transcription initiation factor TFIID subunit 8; cDNA FLJ57866, highly similar to Homo sapiens TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, mRNA Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] Show all	234 aa 26.4 kDa	No	0
TAF8-009 ENSP00000417760 ENST00000472818	C9J7M8 [Direct mapping] Transcription initiation factor TFIID subunit 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0046982 [protein heterodimerization activity] Show all	123 aa 13.2 kDa	No	0
TAF8-010 ENSP00000417738 ENST00000482432	C9J856 [Direct mapping] Transcription initiation factor TFIID subunit 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		60 aa 6.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.