Cell atlas - FGFBP1 - The Human Protein Atlas

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FGFBP1

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	FGFBP1
Gene description	Fibroblast growth factor binding protein 1
Protein class	Cancer-related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (HaCaT, CAPAN-2, A-431, hTCEpi)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HaCaT, CAPAN-2, A-431, hTCEpi) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	FGFBP1 (HGNC Symbol)
Synonyms	FGFBP, HBP17
Description	Fibroblast growth factor binding protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]
Chromosome	4
Cytoband	p15.32
Chromosome location (bp)	15935569 - 15938740
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137440 (version 83.38)
Entrez gene	9982
UniProt	Q14512 (UniProt - Evidence at protein level)
neXtProt	NX_Q14512
Antibodypedia	FGFBP1 antibodies

PROTEIN BROWSER

FGFBP1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FGFBP1-001 ENSP00000371770 ENST00000382333	Q14512 [Direct mapping] Fibroblast growth factor-binding protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009986 [cell surface] GO:0017134 [fibroblast growth factor binding] GO:0045743 [positive regulation of fibroblast growth factor receptor signaling pathway] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	234 aa 26.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.