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FGFBP1

GENERAL INFORMATION

Gene name

 FGFBP1

Gene description

 Fibroblast growth factor binding protein 1

Protein class

 Cancer-related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (esophagus)
GTEx:Group enriched (esophagus, vagina, cervix, uterine, salivary gland, skin)
FANTOM5:Group enriched (esophagus, tonsil, cervix, uterine)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct cytoplasmic and membranous expression in squamous epithelium.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA004332
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (esophagus)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, vagina, cervix, uterine, salivary gland, skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, tonsil, cervix, uterine)

GENE INFORMATION

Gene name

 FGFBP1 (HGNC Symbol)

Synonyms

 FGFBP, HBP17

Description

 Fibroblast growth factor binding protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]

Chromosome

 4

Cytoband

 p15.32

Chromosome location (bp)

 15935569 - 15938740

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137440 (version 83.38)

Entrez gene

 9982

UniProt

 Q14512 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14512

Antibodypedia

 FGFBP1 antibodies

PROTEIN BROWSER
FGFBP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FGFBP1-001
ENSP00000371770
ENST00000382333
Q14512 [Direct mapping]
Fibroblast growth factor-binding protein 1
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002230 [positive regulation of defense response to virus by host]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0017134 [fibroblast growth factor binding]
GO:0045743 [positive regulation of fibroblast growth factor receptor signaling pathway]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
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 234 aa
26.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.