Tissue expression of SLC37A4 - Summary - The Human Protein Atlas

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SLC37A4

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SLC37A4
Gene description	Solute carrier family 37 (glucose-6-phosphate transporter), member 4
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (kidney, duodenum)
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in renal tubules, hepatocytes and the intestines. Also expressed other cell types as well.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA038939 , HPA038940
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

N/A

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (kidney, duodenum)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SLC37A4 (HGNC Symbol)
Synonyms	G6PT1, G6PT2, G6PT3, GSD1b, GSD1c, GSD1d
Description	Solute carrier family 37 (glucose-6-phosphate transporter), member 4 (HGNC Symbol)
Entrez gene summary	This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants.[provided by RefSeq, Aug 2009]
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	119024114 - 119030906
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137700 (version 83.38)
Entrez gene	2542
UniProt
neXtProt
Antibodypedia	SLC37A4 antibodies

PROTEIN BROWSER

SLC37A4-201	SLC37A4-202	SLC37A4-203	SLC37A4-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC37A4-201 ENSP00000476242 ENST00000330775	U3KPU7 [Direct mapping] Glucose-6-phosphate translocase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	429 aa 46.4 kDa	No	>9
SLC37A4-202 ENSP00000476176 ENST00000357590	U3KQS2 [Direct mapping] Glucose-6-phosphate translocase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001780 [neutrophil homeostasis] GO:0001816 [cytokine production] GO:0002318 [myeloid progenitor cell differentiation] GO:0005215 [transporter activity] GO:0005977 [glycogen metabolic process] GO:0006089 [lactate metabolic process] GO:0006641 [triglyceride metabolic process] GO:0006810 [transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007584 [response to nutrient] GO:0008202 [steroid metabolic process] GO:0009749 [response to glucose] GO:0014070 [response to organic cyclic compound] GO:0015152 [glucose-6-phosphate transmembrane transporter activity] GO:0015760 [glucose-6-phosphate transport] GO:0016021 [integral component of membrane] GO:0030593 [neutrophil chemotaxis] GO:0032682 [negative regulation of chemokine production] GO:0035166 [post-embryonic hemopoiesis] GO:0042632 [cholesterol homeostasis] GO:0043085 [positive regulation of catalytic activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0045730 [respiratory burst] GO:0055085 [transmembrane transport] Show all	451 aa 48.9 kDa	No	>9
SLC37A4-203 ENSP00000475991 ENST00000538950	U3KQL4 [Direct mapping] Glucose-6-phosphate translocase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	356 aa 38.3 kDa	No	9
SLC37A4-204 ENSP00000475241 ENST00000545985	U3KPU7 [Direct mapping] Glucose-6-phosphate translocase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	429 aa 46.4 kDa	No	>9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.