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RDX
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

RDX

Gene description

Radixin

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression at variable levels in several different cell types. Most abundant in adrenal gland and renal tubules.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

Supported based on 3 antibodies.
HPA000263 , HPA000763 , CAB037312
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin050100150200TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin020406080100120RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina020406080100120140Tags Per Million

GENE INFORMATION

Gene name

RDX (HGNC Symbol)

Synonyms

DFNB24

Description

Radixin (HGNC Symbol)

Entrez gene summary

Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Chromosome

11

Cytoband

q22.3

Chromosome location (bp)

110174880 - 110296722

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137710 (version 83.38)

Entrez gene

5962

UniProt

P35241 (UniProt - Evidence at protein level)

neXtProt

NX_P35241

Antibodypedia

RDX antibodies

PROTEIN BROWSER

RDX-001
RDX-002
RDX-003
RDX-004
RDX-006
RDX-010
RDX-012
RDX-014
RDX-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RDX-001
ENSP00000342830
ENST00000343115
P35241 [Direct mapping]
Radixin
B0YJ88 [Target identity:100%; Query identity:100%]
Radixin; Radixin, isoform CRA_b; cDNA, FLJ93349, Homo sapiens radixin (RDX), mRNA
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005925 [focal adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0008361 [regulation of cell size]
GO:0010628 [positive regulation of gene expression]
GO:0010737 [protein kinase A signaling]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0030864 [cortical actin cytoskeleton]
GO:0032154 [cleavage furrow]
GO:0032231 [regulation of actin filament bundle assembly]
GO:0032487 [regulation of Rap protein signal transduction]
GO:0034111 [negative regulation of homotypic cell-cell adhesion]
GO:0034260 [negative regulation of GTPase activity]
GO:0042803 [protein homodimerization activity]
GO:0043087 [regulation of GTPase activity]
GO:0044822 [poly(A) RNA binding]
GO:0045184 [establishment of protein localization]
GO:0045792 [negative regulation of cell size]
GO:0051018 [protein kinase A binding]
GO:0051117 [ATPase binding]
GO:0051693 [actin filament capping]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0097067 [cellular response to thyroid hormone stimulus]
GO:1900027 [regulation of ruffle assembly]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1902115 [regulation of organelle assembly]
GO:1902966 [positive regulation of protein localization to early endosome]
GO:1903364 [positive regulation of cellular protein catabolic process]
GO:1903392 [negative regulation of adherens junction organization]
GO:2000643 [positive regulation of early endosome to late endosome transport]
Show all
583 aa
68.6 kDa
No 0
RDX-002
ENSP00000384136
ENST00000405097
P35241 [Direct mapping]
Radixin
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005925 [focal adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0008361 [regulation of cell size]
GO:0010628 [positive regulation of gene expression]
GO:0010737 [protein kinase A signaling]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0019904 [protein domain specific binding]
GO:0030027 [lamellipodium]
GO:0030033 [microvillus assembly]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0030864 [cortical actin cytoskeleton]
GO:0032154 [cleavage furrow]
GO:0032231 [regulation of actin filament bundle assembly]
GO:0032420 [stereocilium]
GO:0032487 [regulation of Rap protein signal transduction]
GO:0034111 [negative regulation of homotypic cell-cell adhesion]
GO:0034260 [negative regulation of GTPase activity]
GO:0042803 [protein homodimerization activity]
GO:0043087 [regulation of GTPase activity]
GO:0043209 [myelin sheath]
GO:0044822 [poly(A) RNA binding]
GO:0045176 [apical protein localization]
GO:0045177 [apical part of cell]
GO:0045184 [establishment of protein localization]
GO:0045792 [negative regulation of cell size]
GO:0051018 [protein kinase A binding]
GO:0051117 [ATPase binding]
GO:0051693 [actin filament capping]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0097067 [cellular response to thyroid hormone stimulus]
GO:1900027 [regulation of ruffle assembly]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1902115 [regulation of organelle assembly]
GO:1902966 [positive regulation of protein localization to early endosome]
GO:1903364 [positive regulation of cellular protein catabolic process]
GO:1903392 [negative regulation of adherens junction organization]
GO:2000643 [positive regulation of early endosome to late endosome transport]
Show all
604 aa
71 kDa
No 0
RDX-003
ENSP00000433580
ENST00000528900
P35241 [Direct mapping]
Radixin
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005925 [focal adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0008361 [regulation of cell size]
GO:0010628 [positive regulation of gene expression]
GO:0010737 [protein kinase A signaling]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0030864 [cortical actin cytoskeleton]
GO:0032154 [cleavage furrow]
GO:0032231 [regulation of actin filament bundle assembly]
GO:0032487 [regulation of Rap protein signal transduction]
GO:0034111 [negative regulation of homotypic cell-cell adhesion]
GO:0034260 [negative regulation of GTPase activity]
GO:0042803 [protein homodimerization activity]
GO:0043087 [regulation of GTPase activity]
GO:0044822 [poly(A) RNA binding]
GO:0045184 [establishment of protein localization]
GO:0045792 [negative regulation of cell size]
GO:0051018 [protein kinase A binding]
GO:0051117 [ATPase binding]
GO:0051693 [actin filament capping]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0097067 [cellular response to thyroid hormone stimulus]
GO:1900027 [regulation of ruffle assembly]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1902115 [regulation of organelle assembly]
GO:1902966 [positive regulation of protein localization to early endosome]
GO:1903364 [positive regulation of cellular protein catabolic process]
GO:1903392 [negative regulation of adherens junction organization]
GO:2000643 [positive regulation of early endosome to late endosome transport]
Show all
257 aa
29.7 kDa
No 0
RDX-004
ENSP00000436277
ENST00000530301
P35241 [Direct mapping]
Radixin
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005925 [focal adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0008361 [regulation of cell size]
GO:0010628 [positive regulation of gene expression]
GO:0010737 [protein kinase A signaling]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0030864 [cortical actin cytoskeleton]
GO:0032154 [cleavage furrow]
GO:0032231 [regulation of actin filament bundle assembly]
GO:0032487 [regulation of Rap protein signal transduction]
GO:0034111 [negative regulation of homotypic cell-cell adhesion]
GO:0034260 [negative regulation of GTPase activity]
GO:0042803 [protein homodimerization activity]
GO:0043087 [regulation of GTPase activity]
GO:0044822 [poly(A) RNA binding]
GO:0045184 [establishment of protein localization]
GO:0045792 [negative regulation of cell size]
GO:0051018 [protein kinase A binding]
GO:0051117 [ATPase binding]
GO:0051693 [actin filament capping]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0097067 [cellular response to thyroid hormone stimulus]
GO:1900027 [regulation of ruffle assembly]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1902115 [regulation of organelle assembly]
GO:1902966 [positive regulation of protein localization to early endosome]
GO:1903364 [positive regulation of cellular protein catabolic process]
GO:1903392 [negative regulation of adherens junction organization]
GO:2000643 [positive regulation of early endosome to late endosome transport]
Show all
200 aa
23.4 kDa
No 0
RDX-006
ENSP00000432112
ENST00000528498
P35241 [Direct mapping]
Radixin
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005925 [focal adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0008361 [regulation of cell size]
GO:0010628 [positive regulation of gene expression]
GO:0010737 [protein kinase A signaling]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0030864 [cortical actin cytoskeleton]
GO:0032154 [cleavage furrow]
GO:0032231 [regulation of actin filament bundle assembly]
GO:0032487 [regulation of Rap protein signal transduction]
GO:0034111 [negative regulation of homotypic cell-cell adhesion]
GO:0034260 [negative regulation of GTPase activity]
GO:0042803 [protein homodimerization activity]
GO:0043087 [regulation of GTPase activity]
GO:0044822 [poly(A) RNA binding]
GO:0045184 [establishment of protein localization]
GO:0045792 [negative regulation of cell size]
GO:0051018 [protein kinase A binding]
GO:0051117 [ATPase binding]
GO:0051693 [actin filament capping]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0097067 [cellular response to thyroid hormone stimulus]
GO:1900027 [regulation of ruffle assembly]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1902115 [regulation of organelle assembly]
GO:1902966 [positive regulation of protein localization to early endosome]
GO:1903364 [positive regulation of cellular protein catabolic process]
GO:1903392 [negative regulation of adherens junction organization]
GO:2000643 [positive regulation of early endosome to late endosome transport]
Show all
604 aa
71 kDa
No 0
RDX-010
ENSP00000432572
ENST00000533991
E9PQ82 [Direct mapping]
Radixin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
Show all
116 aa
13.5 kDa
No 0
RDX-012
ENSP00000431560
ENST00000534683
E9PKN5 [Direct mapping]
Radixin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
Show all
51 aa
6 kDa
No 0
RDX-014
ENSP00000437140
ENST00000532118
E9PNV3 [Direct mapping]
Radixin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
Show all
148 aa
17.3 kDa
No 0
RDX-201
ENSP00000445826
ENST00000544551
P35241 [Direct mapping]
Radixin
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005925 [focal adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0008361 [regulation of cell size]
GO:0010628 [positive regulation of gene expression]
GO:0010737 [protein kinase A signaling]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0030864 [cortical actin cytoskeleton]
GO:0032154 [cleavage furrow]
GO:0032231 [regulation of actin filament bundle assembly]
GO:0032487 [regulation of Rap protein signal transduction]
GO:0034111 [negative regulation of homotypic cell-cell adhesion]
GO:0034260 [negative regulation of GTPase activity]
GO:0042803 [protein homodimerization activity]
GO:0043087 [regulation of GTPase activity]
GO:0044822 [poly(A) RNA binding]
GO:0045184 [establishment of protein localization]
GO:0045792 [negative regulation of cell size]
GO:0051018 [protein kinase A binding]
GO:0051117 [ATPase binding]
GO:0051693 [actin filament capping]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0097067 [cellular response to thyroid hormone stimulus]
GO:1900027 [regulation of ruffle assembly]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1902115 [regulation of organelle assembly]
GO:1902966 [positive regulation of protein localization to early endosome]
GO:1903364 [positive regulation of cellular protein catabolic process]
GO:1903392 [negative regulation of adherens junction organization]
GO:2000643 [positive regulation of early endosome to late endosome transport]
Show all
447 aa
52.7 kDa
No 0

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