Cell atlas - FDX1 - The Human Protein Atlas

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FDX1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	FDX1
Gene description	Ferredoxin 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (validated)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA041630 , HPA062087
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA041630	A-431	Mitochondria
HPA041630	U-2 OS	Mitochondria
HPA041630	U-251 MG	Mitochondria
HPA062087	CACO-2	Mitochondria	Intensity
HPA062087	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	FDX1 (HGNC Symbol)
Synonyms	ADX, FDX
Description	Ferredoxin 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this functional gene are found on chromosomes 20 and 21. [provided by RefSeq, Aug 2011]
Chromosome	11
Cytoband	q22.3
Chromosome location (bp)	110429883 - 110464881
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137714 (version 83.38)
Entrez gene	2230
UniProt	P10109 (UniProt - Evidence at protein level)
neXtProt	NX_P10109
Antibodypedia	FDX1 antibodies

PROTEIN BROWSER

FDX1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FDX1-001 ENSP00000260270 ENST00000260270	P10109 [Direct mapping] Adrenodoxin, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006700 [C21-steroid hormone biosynthetic process] GO:0006805 [xenobiotic metabolic process] GO:0008202 [steroid metabolic process] GO:0008203 [cholesterol metabolic process] GO:0009055 [electron carrier activity] GO:0016125 [sterol metabolic process] GO:0042446 [hormone biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0051536 [iron-sulfur cluster binding] GO:0051537 [2 iron, 2 sulfur cluster binding] GO:0055114 [oxidation-reduction process] Show all	184 aa 19.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.