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FDX1

GENERAL INFORMATION

Gene name

 FDX1

Gene description

 Ferredoxin 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (adrenal gland)
GTEx:Tissue enriched (adrenal gland)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in adrenal gland and Leydig cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA041630 , HPA062087
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adrenal gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FDX1 (HGNC Symbol)

Synonyms

 ADX, FDX

Description

 Ferredoxin 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this functional gene are found on chromosomes 20 and 21. [provided by RefSeq, Aug 2011]

Chromosome

 11

Cytoband

 q22.3

Chromosome location (bp)

 110429883 - 110464881

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137714 (version 83.38)

Entrez gene

 2230

UniProt

 P10109 (UniProt - Evidence at protein level)

neXtProt

 NX_P10109

Antibodypedia

 FDX1 antibodies

PROTEIN BROWSER
FDX1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FDX1-001
ENSP00000260270
ENST00000260270
P10109 [Direct mapping]
Adrenodoxin, mitochondrial
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005506 [iron ion binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006700 [C21-steroid hormone biosynthetic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008202 [steroid metabolic process]
GO:0008203 [cholesterol metabolic process]
GO:0009055 [electron carrier activity]
GO:0016125 [sterol metabolic process]
GO:0042446 [hormone biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0051536 [iron-sulfur cluster binding]
GO:0051537 [2 iron, 2 sulfur cluster binding]
GO:0055114 [oxidation-reduction process]
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 184 aa
19.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.