Expression of NDUFAF1 in cancer - Summary

CANCER ATLAS

Gene description

NADH dehydrogenase (ubiquinone) complex I, assembly factor 1

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA039933	HPA040064

GENE INFORMATION
Gene name	NDUFAF1 (HGNC Symbol)
Synonyms	CGI-65, CIA30
Description	NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a complex I assembly factor protein. Complex I (NADH-ubiquinone oxidoreductase) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. The encoded protein is required for assembly of complex I, and mutations in this gene are a cause of mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Dec 2011]
Chromosome	15
Cytoband	q15.1
Chromosome location (bp)	41387349 - 41402519
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137806 (version 83.38)
Entrez gene	51103
UniProt	Q9Y375 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y375
Antibodypedia	NDUFAF1 antibodies

PROTEIN BROWSER

NDUFAF1-001	NDUFAF1-003	NDUFAF1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NDUFAF1-001 ENSP00000260361 ENST00000260361	Q9Y375 [Direct mapping] Complex I intermediate-associated protein 30, mitochondrial A0A024R9L0 [Target identity:100%; Query identity:100%] NADH dehydrogenase (Ubiquinone) 1 alpha subcomplex, assembly factor 1, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005747 [mitochondrial respiratory chain complex I] GO:0006120 [mitochondrial electron transport, NADH to ubiquinone] GO:0006461 [protein complex assembly] GO:0051082 [unfolded protein binding] Show all	327 aa 37.8 kDa	No	0
NDUFAF1-003 ENSP00000453944 ENST00000560978	H0YNB7 [Direct mapping] Complex I intermediate-associated protein 30, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	209 aa 23.8 kDa	No	0
NDUFAF1-004 ENSP00000454083 ENST00000558719	H0YNN4 [Direct mapping] Complex I intermediate-associated protein 30, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	191 aa 21.6 kDa	No	0