Cell atlas - NDUFAF1 - The Human Protein Atlas

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NDUFAF1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	NDUFAF1
Gene description	NADH dehydrogenase (ubiquinone) complex I, assembly factor 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA039933 , HPA040064
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA039933	A-431	Cytosol
HPA039933	U-2 OS	Cytosol
HPA039933	U-251 MG	Cytosol
HPA040064	A-431	Cytosol
HPA040064	U-2 OS	Cytosol
HPA040064	U-251 MG	Cytosol

GENE INFORMATION
Gene name	NDUFAF1 (HGNC Symbol)
Synonyms	CGI-65, CIA30
Description	NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a complex I assembly factor protein. Complex I (NADH-ubiquinone oxidoreductase) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. The encoded protein is required for assembly of complex I, and mutations in this gene are a cause of mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Dec 2011]
Chromosome	15
Cytoband	q15.1
Chromosome location (bp)	41387349 - 41402519
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137806 (version 83.38)
Entrez gene	51103
UniProt	Q9Y375 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y375
Antibodypedia	NDUFAF1 antibodies

PROTEIN BROWSER

NDUFAF1-001	NDUFAF1-003	NDUFAF1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NDUFAF1-001 ENSP00000260361 ENST00000260361	Q9Y375 [Direct mapping] Complex I intermediate-associated protein 30, mitochondrial A0A024R9L0 [Target identity:100%; Query identity:100%] NADH dehydrogenase (Ubiquinone) 1 alpha subcomplex, assembly factor 1, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005747 [mitochondrial respiratory chain complex I] GO:0006120 [mitochondrial electron transport, NADH to ubiquinone] GO:0006461 [protein complex assembly] GO:0051082 [unfolded protein binding] Show all	327 aa 37.8 kDa	No	0
NDUFAF1-003 ENSP00000453944 ENST00000560978	H0YNB7 [Direct mapping] Complex I intermediate-associated protein 30, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	209 aa 23.8 kDa	No	0
NDUFAF1-004 ENSP00000454083 ENST00000558719	H0YNN4 [Direct mapping] Complex I intermediate-associated protein 30, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	191 aa 21.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.