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RTF1

GENERAL INFORMATION

Gene name

 RTF1

Gene description

 RTF1 homolog, Paf1/RNA polymerase II complex component

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA006714
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Oral mucosa

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RTF1 (HGNC Symbol)

Synonyms

 KIAA0252

Description

 RTF1 homolog, Paf1/RNA polymerase II complex component (HGNC Symbol)

Entrez gene summary

 This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in other organisms. The encoded protein may bind single-stranded DNA. [provided by RefSeq, Sep 2010]

Chromosome

 15

Cytoband

 q15.1

Chromosome location (bp)

 41408408 - 41483563

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137815 (version 83.38)

Entrez gene

 23168

UniProt

 Q92541 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92541

Antibodypedia

 RTF1 antibodies

PROTEIN BROWSER
RTF1-001
RTF1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RTF1-001
ENSP00000374280
ENST00000389629
Q92541 [Direct mapping]
RNA polymerase-associated protein RTF1 homolog
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001711 [endodermal cell fate commitment]
GO:0001832 [blastocyst growth]
GO:0003677 [DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0016055 [Wnt signaling pathway]
GO:0016570 [histone modification]
GO:0016593 [Cdc73/Paf1 complex]
GO:0019827 [stem cell population maintenance]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
GO:0044822 [poly(A) RNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0080182 [histone H3-K4 trimethylation]
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 710 aa
80.3 kDa 		No 0
RTF1-007
ENSP00000452973
ENST00000560447
H0YKX1 [Direct mapping]
RNA polymerase-associated protein RTF1 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0016570 [histone modification]
GO:0016593 [Cdc73/Paf1 complex]
Show all
 171 aa
20.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.