Cell atlas - RMDN3 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	RMDN3
Gene description	Regulator of microtubule dynamics 3
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (validated)
siRNA	The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA009975
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ASSAYS

RNA expression

Human cells

siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA009975	A-431	Mitochondria
HPA009975	U-2 OS	Mitochondria
HPA009975	U-251 MG	Mitochondria

siRNA VALIDATION

Relative fluorescence intensity (RFI)

Antibody

HPA009975

siRNA validation

Validated: Significant downregulation > 25% by both siRNA:s.

Analysis performed in

Cytoplasmic region of segmented cells in 10x-images

siRNA 1

siRNA 2

RFI

60%

49%

p-value

< 0.01


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Sample	Cell line
HPA009975	siRNA 1	U-2 OS
HPA009975	siRNA 2	U-2 OS
HPA009975	scrambled	U-2 OS

GENE INFORMATION
Gene name	RMDN3 (HGNC Symbol)
Synonyms	FAM82A2, FAM82C, FLJ10579, PTPIP51, RMD3
Description	Regulator of microtubule dynamics 3 (HGNC Symbol)
Entrez gene summary
Chromosome	15
Cytoband	q15.1
Chromosome location (bp)	40735884 - 40755851
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137824 (version 83.38)
Entrez gene	55177
UniProt	Q96TC7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96TC7
Antibodypedia	RMDN3 antibodies

PROTEIN BROWSER

RMDN3-001	RMDN3-003	RMDN3-007	RMDN3-008	RMDN3-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RMDN3-001 ENSP00000260385 ENST00000260385	Q96TC7 [Direct mapping] Regulator of microtubule dynamics protein 3 A0A024R9P6 [Target identity:100%; Query identity:100%] Family with sequence similarity 82, member C, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005874 [microtubule] GO:0006874 [cellular calcium ion homeostasis] GO:0006915 [apoptotic process] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] Show all	470 aa 52.1 kDa	No	1
RMDN3-003 ENSP00000342493 ENST00000338376	Q96TC7 [Direct mapping] Regulator of microtubule dynamics protein 3 A0A024R9P6 [Target identity:100%; Query identity:100%] Family with sequence similarity 82, member C, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005874 [microtubule] GO:0006874 [cellular calcium ion homeostasis] GO:0006915 [apoptotic process] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] Show all	470 aa 52.1 kDa	No	1
RMDN3-007 ENSP00000453199 ENST00000560905	H0YLG5 [Direct mapping] Regulator of microtubule dynamics protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	287 aa 31.3 kDa	No	1
RMDN3-008 ENSP00000453978 ENST00000560460	H0YNE5 [Direct mapping] Regulator of microtubule dynamics protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	251 aa 27.4 kDa	No	1
RMDN3-012 ENSP00000453535 ENST00000558232	H0YMB1 [Direct mapping] Regulator of microtubule dynamics protein 3 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		306 aa 34 kDa	No	0