Expression of GCHFR in cancer - Summary

CANCER ATLAS

Gene description

GTP cyclohydrolase I feedback regulator

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA046258

GENE INFORMATION
Gene name	GCHFR (HGNC Symbol)
Synonyms	GFRP, HsT16933
Description	GTP cyclohydrolase I feedback regulator (HGNC Symbol)
Entrez gene summary	GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q15.1
Chromosome location (bp)	40764020 - 40767710
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137880 (version 83.38)
Entrez gene	2644
UniProt	P30047 (UniProt - Evidence at protein level)
neXtProt	NX_P30047
Antibodypedia	GCHFR antibodies

PROTEIN BROWSER

GCHFR-001	GCHFR-002	GCHFR-003	GCHFR-004	GCHFR-005	GCHFR-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GCHFR-001 ENSP00000260447 ENST00000260447	P30047 [Direct mapping] GTP cyclohydrolase 1 feedback regulatory protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004857 [enzyme inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006461 [protein complex assembly] GO:0006809 [nitric oxide biosynthetic process] GO:0009890 [negative regulation of biosynthetic process] GO:0016597 [amino acid binding] GO:0019899 [enzyme binding] GO:0030425 [dendrite] GO:0030742 [GTP-dependent protein binding] GO:0031965 [nuclear membrane] GO:0042133 [neurotransmitter metabolic process] GO:0042470 [melanosome] GO:0043105 [negative regulation of GTP cyclohydrolase I activity] GO:0043234 [protein complex] GO:0044281 [small molecule metabolic process] GO:0044549 [GTP cyclohydrolase binding] GO:0046209 [nitric oxide metabolic process] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051291 [protein heterooligomerization] Show all	84 aa 9.7 kDa	No	0
GCHFR-002 ENSP00000453871 ENST00000559445	P30047 [Direct mapping] GTP cyclohydrolase 1 feedback regulatory protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006809 [nitric oxide biosynthetic process] GO:0009890 [negative regulation of biosynthetic process] GO:0030425 [dendrite] GO:0031965 [nuclear membrane] GO:0042133 [neurotransmitter metabolic process] GO:0042470 [melanosome] GO:0043105 [negative regulation of GTP cyclohydrolase I activity] GO:0044281 [small molecule metabolic process] GO:0044549 [GTP cyclohydrolase binding] GO:0046209 [nitric oxide metabolic process] GO:0050999 [regulation of nitric-oxide synthase activity] Show all	73 aa 8.6 kDa	No	0
GCHFR-003 ENSP00000454067 ENST00000561160	H0YNM1 [Direct mapping] GTP cyclohydrolase 1 feedback regulatory protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0009890 [negative regulation of biosynthetic process] Show all	44 aa 4.9 kDa	No	0
GCHFR-004 ENSP00000477896 ENST00000558670	A0A087WTI4 [Direct mapping] GTP cyclohydrolase 1 feedback regulatory protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		13 aa 1.6 kDa	No	0
GCHFR-005 ENSP00000454195 ENST00000559932	H0YNX7 [Direct mapping] GTP cyclohydrolase 1 feedback regulatory protein; GTP cyclohydrolase I feedback regulator, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0009890 [negative regulation of biosynthetic process] GO:0016787 [hydrolase activity] Show all	67 aa 7.8 kDa	No	0
GCHFR-006 ENSP00000453640 ENST00000558467	H0YNX7 [Direct mapping] GTP cyclohydrolase 1 feedback regulatory protein; GTP cyclohydrolase I feedback regulator, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0009890 [negative regulation of biosynthetic process] GO:0016787 [hydrolase activity] Show all	67 aa 7.8 kDa	No	0