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GCHFR

GENERAL INFORMATION

Gene name

 GCHFR

Gene description

 GTP cyclohydrolase I feedback regulator

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA046258
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GCHFR (HGNC Symbol)

Synonyms

 GFRP, HsT16933

Description

 GTP cyclohydrolase I feedback regulator (HGNC Symbol)

Entrez gene summary

 GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q15.1

Chromosome location (bp)

 40764020 - 40767710

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137880 (version 83.38)

Entrez gene

 2644

UniProt

 P30047 (UniProt - Evidence at protein level)

neXtProt

 NX_P30047

Antibodypedia

 GCHFR antibodies

PROTEIN BROWSER
GCHFR-001
GCHFR-002
GCHFR-003
GCHFR-004
GCHFR-005
GCHFR-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GCHFR-001
ENSP00000260447
ENST00000260447
P30047 [Direct mapping]
GTP cyclohydrolase 1 feedback regulatory protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004857 [enzyme inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006461 [protein complex assembly]
GO:0006809 [nitric oxide biosynthetic process]
GO:0009890 [negative regulation of biosynthetic process]
GO:0016597 [amino acid binding]
GO:0019899 [enzyme binding]
GO:0030425 [dendrite]
GO:0030742 [GTP-dependent protein binding]
GO:0031965 [nuclear membrane]
GO:0042133 [neurotransmitter metabolic process]
GO:0042470 [melanosome]
GO:0043105 [negative regulation of GTP cyclohydrolase I activity]
GO:0043234 [protein complex]
GO:0044281 [small molecule metabolic process]
GO:0044549 [GTP cyclohydrolase binding]
GO:0046209 [nitric oxide metabolic process]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051291 [protein heterooligomerization]
Show all
 84 aa
9.7 kDa 		No 0
GCHFR-002
ENSP00000453871
ENST00000559445
P30047 [Direct mapping]
GTP cyclohydrolase 1 feedback regulatory protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006809 [nitric oxide biosynthetic process]
GO:0009890 [negative regulation of biosynthetic process]
GO:0030425 [dendrite]
GO:0031965 [nuclear membrane]
GO:0042133 [neurotransmitter metabolic process]
GO:0042470 [melanosome]
GO:0043105 [negative regulation of GTP cyclohydrolase I activity]
GO:0044281 [small molecule metabolic process]
GO:0044549 [GTP cyclohydrolase binding]
GO:0046209 [nitric oxide metabolic process]
GO:0050999 [regulation of nitric-oxide synthase activity]
Show all
 73 aa
8.6 kDa 		No 0
GCHFR-003
ENSP00000454067
ENST00000561160
H0YNM1 [Direct mapping]
GTP cyclohydrolase 1 feedback regulatory protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0009890 [negative regulation of biosynthetic process]
Show all
 44 aa
4.9 kDa 		No 0
GCHFR-004
ENSP00000477896
ENST00000558670
A0A087WTI4 [Direct mapping]
GTP cyclohydrolase 1 feedback regulatory protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 13 aa
1.6 kDa 		No 0
GCHFR-005
ENSP00000454195
ENST00000559932
H0YNX7 [Direct mapping]
GTP cyclohydrolase 1 feedback regulatory protein; GTP cyclohydrolase I feedback regulator, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0009890 [negative regulation of biosynthetic process]
GO:0016787 [hydrolase activity]
Show all
 67 aa
7.8 kDa 		No 0
GCHFR-006
ENSP00000453640
ENST00000558467
H0YNX7 [Direct mapping]
GTP cyclohydrolase 1 feedback regulatory protein; GTP cyclohydrolase I feedback regulator, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0009890 [negative regulation of biosynthetic process]
GO:0016787 [hydrolase activity]
Show all
 67 aa
7.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.