Expression of CCBL2 in cancer - Summary

CANCER ATLAS

Gene description

Cysteine conjugate-beta lyase 2

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA026538	HPA027168

GENE INFORMATION
Gene name	CCBL2 (HGNC Symbol)
Synonyms	KAT3, RBM1, RP11-82K18.3
Description	Cysteine conjugate-beta lyase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes an aminotransferase that transaminates kynurenine to form kynurenic acid. Kynurenic acid is a metabolite of tryptophan. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene. This gene shares 5' exon structure with the RNA binding motif protein, X-linked-like 1 locus on chromosome 1, but the coding sequences are non-overlapping. [provided by RefSeq, Jun 2009]
Chromosome	1
Cytoband	p22.2
Chromosome location (bp)	88935773 - 88992953
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137944 (version 83.38)
Entrez gene	56267
UniProt	Q6YP21 (UniProt - Evidence at protein level)
neXtProt	NX_Q6YP21
Antibodypedia	CCBL2 antibodies

PROTEIN BROWSER

CCBL2-001	CCBL2-003	CCBL2-004	CCBL2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCBL2-001 ENSP00000359522 ENST00000370491	Q6YP21 [Direct mapping] Kynurenine--oxoglutarate transaminase 3 Show all	Enzymes ENZYME proteins Transferases Lyases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006520 [cellular amino acid metabolic process] GO:0006569 [tryptophan catabolic process] GO:0009058 [biosynthetic process] GO:0016212 [kynurenine-oxoglutarate transaminase activity] GO:0030170 [pyridoxal phosphate binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] GO:0047315 [kynurenine-glyoxylate transaminase activity] GO:0047804 [cysteine-S-conjugate beta-lyase activity] GO:0070189 [kynurenine metabolic process] GO:0097052 [L-kynurenine metabolic process] Show all	420 aa 47.8 kDa	No	0
CCBL2-003 ENSP00000359517 ENST00000370486	A0A0A0MRN7 [Direct mapping] Kynurenine--oxoglutarate transaminase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0009058 [biosynthetic process] GO:0030170 [pyridoxal phosphate binding] Show all	262 aa 29.5 kDa	No	0
CCBL2-004 ENSP00000260508 ENST00000260508	Q6YP21 [Direct mapping] Kynurenine--oxoglutarate transaminase 3 B4DW13 [Target identity:100%; Query identity:100%] HCG23341, isoform CRA_d; cDNA FLJ56161, highly similar to Homo sapiens kynurenine aminotransferase III (KAT3), transcript variant 1, mRNA; cDNA, FLJ78816, highly similar to Homo sapiens kynurenine aminotransferase III (KAT3), transcript variant 1, mRNA Show all	Enzymes ENZYME proteins Transferases Lyases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0006103 [2-oxoglutarate metabolic process] GO:0006520 [cellular amino acid metabolic process] GO:0006569 [tryptophan catabolic process] GO:0009058 [biosynthetic process] GO:0016212 [kynurenine-oxoglutarate transaminase activity] GO:0030170 [pyridoxal phosphate binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] GO:0047315 [kynurenine-glyoxylate transaminase activity] GO:0047804 [cysteine-S-conjugate beta-lyase activity] GO:0070189 [kynurenine metabolic process] GO:0097052 [L-kynurenine metabolic process] Show all	454 aa 51.4 kDa	No	0
CCBL2-201 ENSP00000359516 ENST00000370485	A0A0A0MRN6 [Direct mapping] Kynurenine--oxoglutarate transaminase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0009058 [biosynthetic process] GO:0030170 [pyridoxal phosphate binding] Show all	175 aa 19.9 kDa	No	0