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CCBL2

GENERAL INFORMATION

Gene name

 CCBL2

Gene description

 Cysteine conjugate-beta lyase 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA026538 , HPA027168
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CCBL2 (HGNC Symbol)

Synonyms

 KAT3, RBM1, RP11-82K18.3

Description

 Cysteine conjugate-beta lyase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes an aminotransferase that transaminates kynurenine to form kynurenic acid. Kynurenic acid is a metabolite of tryptophan. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene. This gene shares 5' exon structure with the RNA binding motif protein, X-linked-like 1 locus on chromosome 1, but the coding sequences are non-overlapping. [provided by RefSeq, Jun 2009]

Chromosome

 1

Cytoband

 p22.2

Chromosome location (bp)

 88935773 - 88992953

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137944 (version 83.38)

Entrez gene

 56267

UniProt

 Q6YP21 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6YP21

Antibodypedia

 CCBL2 antibodies

PROTEIN BROWSER
CCBL2-001
CCBL2-003
CCBL2-004
CCBL2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCBL2-001
ENSP00000359522
ENST00000370491
Q6YP21 [Direct mapping]
Kynurenine--oxoglutarate transaminase 3
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Enzymes
   ENZYME proteins
   Transferases
   Lyases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006520 [cellular amino acid metabolic process]
GO:0006569 [tryptophan catabolic process]
GO:0009058 [biosynthetic process]
GO:0016212 [kynurenine-oxoglutarate transaminase activity]
GO:0030170 [pyridoxal phosphate binding]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0047315 [kynurenine-glyoxylate transaminase activity]
GO:0047804 [cysteine-S-conjugate beta-lyase activity]
GO:0070189 [kynurenine metabolic process]
GO:0097052 [L-kynurenine metabolic process]
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 420 aa
47.8 kDa 		No 0
CCBL2-003
ENSP00000359517
ENST00000370486
A0A0A0MRN7 [Direct mapping]
Kynurenine--oxoglutarate transaminase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0009058 [biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
Show all
 262 aa
29.5 kDa 		No 0
CCBL2-004
ENSP00000260508
ENST00000260508
Q6YP21 [Direct mapping]
Kynurenine--oxoglutarate transaminase 3
B4DW13 [Target identity:100%; Query identity:100%]
HCG23341, isoform CRA_d; cDNA FLJ56161, highly similar to Homo sapiens kynurenine aminotransferase III (KAT3), transcript variant 1, mRNA; cDNA, FLJ78816, highly similar to Homo sapiens kynurenine aminotransferase III (KAT3), transcript variant 1, mRNA
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Enzymes
   ENZYME proteins
   Transferases
   Lyases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006520 [cellular amino acid metabolic process]
GO:0006569 [tryptophan catabolic process]
GO:0009058 [biosynthetic process]
GO:0016212 [kynurenine-oxoglutarate transaminase activity]
GO:0030170 [pyridoxal phosphate binding]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0047315 [kynurenine-glyoxylate transaminase activity]
GO:0047804 [cysteine-S-conjugate beta-lyase activity]
GO:0070189 [kynurenine metabolic process]
GO:0097052 [L-kynurenine metabolic process]
Show all
 454 aa
51.4 kDa 		No 0
CCBL2-201
ENSP00000359516
ENST00000370485
A0A0A0MRN6 [Direct mapping]
Kynurenine--oxoglutarate transaminase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0009058 [biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
Show all
 175 aa
19.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.