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RAB1A

CANCER ATLAS

Gene description

 RAB1A, member RAS oncogene family

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA056141
CAB005331

GENE INFORMATION

Gene name

 RAB1A (HGNC Symbol)

Synonyms

 RAB1, YPT1

Description

 RAB1A, member RAS oncogene family (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. [provided by RefSeq, Oct 2008]

Chromosome

 2

Cytoband

 p14

Chromosome location (bp)

 65070701 - 65130106

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138069 (version 83.38)

Entrez gene

 5861

UniProt

 P62820 (UniProt - Evidence at protein level)

neXtProt

 NX_P62820

Antibodypedia

 RAB1A antibodies

PROTEIN BROWSER
RAB1A-001
RAB1A-002
RAB1A-003
RAB1A-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAB1A-001
ENSP00000387286
ENST00000409784
P62820 [Direct mapping]
Ras-related protein Rab-1A
Q5U0I6 [Target identity:100%; Query identity:100%]
H.sapiens ras-related Hrab1A protein; RAB1A protein; RAB1A, member RAS oncogene family; RAB1A, member RAS oncogene family, isoform CRA_b; cDNA, FLJ96558, Homo sapiens RAB1A, member RAS oncogene family (RAB1A), mRNA
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005769 [early endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0006913 [nucleocytoplasmic transport]
GO:0006914 [autophagy]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0016477 [cell migration]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019068 [virion assembly]
GO:0030252 [growth hormone secretion]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0042470 [melanosome]
GO:0042742 [defense response to bacterium]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0047496 [vesicle transport along microtubule]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0072606 [interleukin-8 secretion]
GO:0090110 [cargo loading into COPII-coated vesicle]
GO:1903020 [positive regulation of glycoprotein metabolic process]
Show all
 205 aa
22.7 kDa 		No 0
RAB1A-002
ENSP00000386451
ENST00000409892
P62820 [Direct mapping]
Ras-related protein Rab-1A
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005769 [early endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0006914 [autophagy]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0016477 [cell migration]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019068 [virion assembly]
GO:0030252 [growth hormone secretion]
GO:0032482 [Rab protein signal transduction]
GO:0042470 [melanosome]
GO:0042742 [defense response to bacterium]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0047496 [vesicle transport along microtubule]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0072606 [interleukin-8 secretion]
GO:0090110 [cargo loading into COPII-coated vesicle]
GO:1903020 [positive regulation of glycoprotein metabolic process]
Show all
 141 aa
15.3 kDa 		No 0
RAB1A-003
ENSP00000386672
ENST00000409751
E7END7 [Direct mapping]
Ras-related protein Rab-1A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0032482 [Rab protein signal transduction]
Show all
 173 aa
19 kDa 		No 0
RAB1A-004
ENSP00000381540
ENST00000398529
P62820 [Direct mapping]
Ras-related protein Rab-1A
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005769 [early endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0006914 [autophagy]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0016477 [cell migration]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019068 [virion assembly]
GO:0030252 [growth hormone secretion]
GO:0032482 [Rab protein signal transduction]
GO:0042470 [melanosome]
GO:0042742 [defense response to bacterium]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0047496 [vesicle transport along microtubule]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0072606 [interleukin-8 secretion]
GO:0090110 [cargo loading into COPII-coated vesicle]
GO:1903020 [positive regulation of glycoprotein metabolic process]
Show all
 129 aa
13.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.