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RAB1A

GENERAL INFORMATION

Gene name

 RAB1A

Gene description

 RAB1A, member RAS oncogene family

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 2 antibodies.
HPA056141 , CAB005331
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RAB1A (HGNC Symbol)

Synonyms

 RAB1, YPT1

Description

 RAB1A, member RAS oncogene family (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. [provided by RefSeq, Oct 2008]

Chromosome

 2

Cytoband

 p14

Chromosome location (bp)

 65070701 - 65130106

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138069 (version 83.38)

Entrez gene

 5861

UniProt

 P62820 (UniProt - Evidence at protein level)

neXtProt

 NX_P62820

Antibodypedia

 RAB1A antibodies

PROTEIN BROWSER
RAB1A-001
RAB1A-002
RAB1A-003
RAB1A-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAB1A-001
ENSP00000387286
ENST00000409784
P62820 [Direct mapping]
Ras-related protein Rab-1A
Q5U0I6 [Target identity:100%; Query identity:100%]
H.sapiens ras-related Hrab1A protein; RAB1A protein; RAB1A, member RAS oncogene family; RAB1A, member RAS oncogene family, isoform CRA_b; cDNA, FLJ96558, Homo sapiens RAB1A, member RAS oncogene family (RAB1A), mRNA
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005769 [early endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0006913 [nucleocytoplasmic transport]
GO:0006914 [autophagy]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0016477 [cell migration]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019068 [virion assembly]
GO:0030252 [growth hormone secretion]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0042470 [melanosome]
GO:0042742 [defense response to bacterium]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0047496 [vesicle transport along microtubule]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0072606 [interleukin-8 secretion]
GO:0090110 [cargo loading into COPII-coated vesicle]
GO:1903020 [positive regulation of glycoprotein metabolic process]
Show all
 205 aa
22.7 kDa 		No 0
RAB1A-002
ENSP00000386451
ENST00000409892
P62820 [Direct mapping]
Ras-related protein Rab-1A
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005769 [early endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0006914 [autophagy]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0016477 [cell migration]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019068 [virion assembly]
GO:0030252 [growth hormone secretion]
GO:0032482 [Rab protein signal transduction]
GO:0042470 [melanosome]
GO:0042742 [defense response to bacterium]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0047496 [vesicle transport along microtubule]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0072606 [interleukin-8 secretion]
GO:0090110 [cargo loading into COPII-coated vesicle]
GO:1903020 [positive regulation of glycoprotein metabolic process]
Show all
 141 aa
15.3 kDa 		No 0
RAB1A-003
ENSP00000386672
ENST00000409751
E7END7 [Direct mapping]
Ras-related protein Rab-1A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0032482 [Rab protein signal transduction]
Show all
 173 aa
19 kDa 		No 0
RAB1A-004
ENSP00000381540
ENST00000398529
P62820 [Direct mapping]
Ras-related protein Rab-1A
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005769 [early endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0006914 [autophagy]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0016477 [cell migration]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019068 [virion assembly]
GO:0030252 [growth hormone secretion]
GO:0032482 [Rab protein signal transduction]
GO:0042470 [melanosome]
GO:0042742 [defense response to bacterium]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0047496 [vesicle transport along microtubule]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0072606 [interleukin-8 secretion]
GO:0090110 [cargo loading into COPII-coated vesicle]
GO:1903020 [positive regulation of glycoprotein metabolic process]
Show all
 129 aa
13.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.